Expressions of Lipid Oxidation Markers, Nε-Hexanoyl Lysine and Acrolein in Cisplatin-Induced Nephrotoxicity in Rats

Akihiko SUGIYAMA; Jing SUN; Masaaki NISHINOHARA; Yuka FUJITA; Aino MASUDA; Tairin OCHI; Takashi TAKEUCHI

doi:10.1292/jvms.10-0476

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Expressions of Lipid Oxidation Markers, N^ε-Hexanoyl Lysine and Acrolein in Cisplatin-Induced Nephrotoxicity in Rats

Akihiko SUGIYAMA, Jing SUN, Masaaki NISHINOHARA, Yuka FUJITA, Aino MASUDA, Tairin OCHI, Takashi TAKEUCHI

著者情報

キーワード: acrolein, cisplatin, nephrotoxicity, N^ε-hexanoyl lysine, oxidative damage

ジャーナルフリー早期公開

論文ID: 10-0476

DOI https://doi.org/10.1292/jvms.10-0476

この記事には本公開記事があります。

The final version of this article is now available: Vol. 73 (2011) , No. 6 p.821

詳細

抄録

The purpose of this study was to evaluate whether N^ε-hexanoyl lysine (N^ε-HEL) and acrolein reflect the severity of cisplatin-induced nephrotoxicity. Immunoexpression of N^ε-HEL and acrolein in kidneys and their urinary concentration were examined up to day 4 post-cisplatin injection in rats. Cisplatin-induced tubular injury was observed histopathologically on days 2–4 after injection and became more severe time-dependently. On days 2–4, N^ε-HEL and acrolein were immunostained in the cytoplasm of damaged tubular cells. Their immunostaining intensity and urinary levels increased as tubular injury became more severe. These results suggest that expressions of N^ε-HEL and acrolein were associated with the pathogenesis of cisplatin-induced nephrotoxicity.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）