抄録
This study was conducted to investigate the prophylactic effects of carnitine against contrast-induced nephropathy (CIN) and its relation to oxidant/antioxidant status in kidney, liver, heart, spleen and lung tissues in CIN rat model. Twenty-eight adult male Wistar rats were divided into four groups as control, contrast media (CM), carnitine, and contrast media+carnitine group (CM+carnitine). Animals were placed in the individual metabolism cages, on the 2nd day, rats were deprived of water for 24 hr. On the 3rd day, contrast media was administered to groups CM and CM+carnitine. The administration of L-carnitine was on days 2, 3 and 4. Histopathological changes were evaluated in right kidney after sacrification. Superoxide dismutase (SOD) and catalase (CAT) activities, and glutathione (GSH) and malondialdehyde (MDA) levels were measured in renal, liver, heart, spleen and lung tissues. SOD activities in renal (P<0.05), liver (P<0.001) and spleen (P<0.05) tissues were increased in carnitine group. CAT activities in spleen tissue were decreased (P<0.01) only in CM group. Renal (P<0.05), liver (P<0.001), spleen (P<0.001) and lung tissues (P<0.01) GSH levels were found higher in carnitine group. In renal, liver and lung tissues MDA levels increased in CM group (P<0.001). Histopathological findings showed that L-carnitine may have a preventative effect in alleviating the negative effects of CIN. Similar to this, L-carnitine may play a major role in stability of antioxidant status in kidney, liver, spleen and lung of CIN rat model.
