抄録
A 68-year-old woman with generalized lymphadenopathy suffered from disconsciousness due to hypercalcemia. The lymph node biopsy showed T-cell non-Hodgkin lymphoma. However, the Southern blot analysis had not recognized human T-cell lymphotropic virus type I (HTLV-I) integration. Therefore, she was not diagnosed as having adult T cell lymphoma. The X-ray film showed punched out shadows in the cranium and osteolytic lesions on her arms. Thirteen days after death, the autopsy and microscopic examination showed massive bone metastatic lesions. parathyroid hormone (PTH), PTH related protein (PTHrP), urine cAMP or 1, 25-dihydroxyvitamin D3 had not increased. Therefore, the hypercalcemia may have been due not to the humoral hypercalcemia, but to osteolytic hypercalcemia resulting from lytic bone metastasis. Lymphoma associated hypercalcemia is mainly due to humoral hypercalcemia. Hypercalcemia with non-Hodgkin lymphoma may be partly due to osteolytic hypercalcemia.
