Drug Delivery System Using Biodegradable Nanoparticles Carrier

Abstract

Recently, many biochemists have identified that chitosan is not rejected by the body and that it can improve the effective and safe delivery of drugs and vaccines with its absorptive power. Also, it has been known that chitosan is suitable for controlled drug release thanks to its advantages of biodegradability and bio-compatibility. As the interest into the extension of human life and personal health has been increased, the pharmaceutical and medical worlds have been making efforts to develop more sustained and effective drug release property in a body. This study investigated the individual drug characteristics and drug release behavior by manufacturing the chitosan patch using insulin, a drug used for treating diabetes, at a low temperature, and further tried to find the optimal condition by adding the skin activating agent to the chitosan patch using NOD (Non Obese Diabetic) mice. According to the analysis using the chitosan-insulin drug and the skin-activating agent, a dramatic decrease in the blood glucose level was achieved. An experiment was performed in vivo by utilizing chitosan nanoparticles as a biopolymer to control the drug delivery rate at an optimal concentration, pH and temperature. It was also observed that the experiment of the drug delivery by nanoparticles containing insulin could effectively lower the blood glucose of the mouse.