Verification of Anti-wrinkle Effect by PLGA Nanoparticles Encapsulating Hyaluronic Acid as Moisturizing Ingredient

Abstract

In recent years, the needs of cosmetic products possessing anti-wrinkle effects are rapidly increasing, and the cosmetic products appealing it’s efficacy sell well. It is common technique to possess moisture on skin surface by adsorbing moisturizing ingredients in order to improve fine wrinkle. The hyaluronic acid widely used as moisturizing ingredients in cosmetics is difficult to retain on skin having oil contents for a long time because of its high hydrophilicity. Also hyaluronic acid molecular size is too large comparing interstitial cells, hence the penetration into horny internal parts is not easy.

The PLGA (Poly-Lactide-co-Glycolide Acid) nanoparticle that we developed has DDS (Drug Delivery System) function such as excellent permeability to the stratum corneum and slow release of encapsulated content in the particle. By using this technology, the hyaluronic acid can be easily delivered deep into the stratum corneum. Therefore, it was thought that the moisturizing zone formed by hyaluronic acid is expected to expand not only the surface layer but also the deep layer of the straum corneum which tend to the new moisturizing effect.

In this paper, we introduce the test result of the skin moisturizing effect and anti-wrinkle effect by using PLGA nanoparticles encapsulating hyaluronic acid.

Graphical Abstract