Although the awareness concerning the prevention of occupational accidents and worker protection seems to have further increased reflecting the recent revision of the Occupational Safety and Health Act, reality is that there are still many harsh sites when looking at the sites handling the powder. There are many circumstances in which environmental improvement does not work effectively because of the variety of properties of the powder, and the cases showing the demand for further improvement of the environment are increasing. This article introduces the achievement of containment technology matching the powder production site as well as the related equipment together with the organizing and understanding of the regulation for the purpose to improve the environment by one rank.
In order to improve fine wrinkles, it is common technique to possess moisture on skin surface by adsorbing moisturizing ingredients. The hyaluronic acid widely used as a moisturizing ingredient in cosmetics is difficult to retain on skin having oil contents for a long time because of its high hydrophilicity. Also it has too large molecular size compared with the interstitial cells that its penetration into horny internal parts is not easy. On the other hand, the PLGA nanoparticle has DDS function such as excellent permeability to the stratum corneum and slow release of encapsulated content in the particle. By using this technology, the hyaluronic acid can be hold in not only the surface layer but also the deep layer of the stratum corneum which would lead to the new moisturizing effect. In this paper, the test results of the skin moisturizing effect and anti-wrinkle effect by using PLGA nanoparticles encapsulating the hyaluronic acid.