抄録
Effects of repeated administrations (i.p. and p.o.) of emestrin on male ICR mice were examined. Mice injected i.p. showed a high mortality (about 70%) with severe peritonitis fibrosa, while those administered orally showed no peritonitis. Lymphatic leukemia and lung tumor (papillary adenoma) were seen in 3 and 2 mice, respectively, out of 18 survived mice during 25 months. There were no significant differences between the administration routes in the incidence and duration of the tumor development. There were neither tumor nor hyperplastic nodules in the liver, although an increase in volume and marked pleomorphism of nuclei of hepatocytes were seen in the central area of hepatic lobules.
