内視鏡的胃粘膜性状からみた血清ペプシノゲン―Helicobacter Pylori感染との関連を含めて―

抄録

A relation between serum pepsinogen I/II (PG I/II) ratio in gastroduodenal diseases and gastric mucosa observed with endoscope, Helicobacter pylori (H. pylori) infection, histological activity in biopsied specimen were studied.
1) PG I/II ratio in H. pylori positive cases was significantly higher than that of negative cases. It was same in patients with gastric ulcer and control group which has no region except atrophic gastritis (each p＜0.001) .
2) According to Oshima's classification of gastric mucosa, which was classified into 5 groups by appearance of vascular pattern in lesser curvature of lower body, PG I/II ratio in H. pylori infected cases decreased with increase of atrophic grade.
3) Histological activity by the Sydney system and PG I/II ratio were examined. It was higher in (-, ±) group, which has no activity, than in (+) , (⧺) , (⧻) groups, which have activity. H. pylori positive rate was low in (-, ±) group. On the other hand, it was high in (+) , (⧺) , (⧻) groups (each 100.0%, 100.0%, 88.2%) .
4) We got a closely reration between PG I/II ratio and histological activity accompanied with H. pylori infection.