抄録
Monoamine oxidases (MAOs) are involved in the degradation of various biogenic amines such as dopamine and serotonin. There exist two isozymes, MAOA and MAOB, and both located on X chromosome. In humans, both MAOs intron 2 contained dinucleodie repeats, MAin2 and MBin2, that have been subjected as candidate genes for mood disorder and Parkinson’s disease. In this study, we surveyed the corresponding regions in nonhuman primates. MAin2 and MBin2 regions were amplified in a total of 37 species from all primate lineages, including each 1 sample for 6 simian and 7 prosimian species. Amplifications of both MAin2 and MBin2 were succeeded in all simian species, but failed in prosimians. The alleles of MAin2 and MBin2 ranged 222-254 bp and 224-284 bp, respectively. Chimpanzees, gorillas, orangutans and gibbons were polymorphic in both MAin2 and MBin2. Common marmosets and tamarins were polymorphic in MAin2 only. In genus Macaca, MBin2 was polymorphic in 15 of the 18 species and 2-11 alleles were observed. On the other hand, MAin2 was not diverse showing 1-2 alleles. Since the MAin2 and MBin2 were associated with mental disorders, they might be useful markers to survey the association with behavior traits in the above primate species.
