シクロデキストリンとの相互作用評価に基づく難溶性薬物の製剤化

抄録

Salt forms are frequently used in solid dosage forms because they can improve aqueous solubility and chemical stability relative to the non-ionic form of the active compound. However, absorption of drugs through biological membranes could be improved by enhancing the solubility of the non-ionic form by using cyclodextrins （CDs） because the non-ionic form is more hydrophobic than the ionic form （salts）. In this paper, the studies about improvement of water solubility and physicochemical characterization of CD-drug interaction in the solid and solution state were introduced using fentanyl base as a model of poorly water soluble drugs （free base） and CDs.