肝臓の造血成分に関する研究-IX

プロミン貧血に対する葉酸の効果及び葉酸と肝精製物或いはビタミンB₁₂との併用効果

抄録

In a preceding paper¹⁾, it has been reported that ?? purified fraction of whale liver at a 5-g fresh liver level was effective to alleviate promin-induced anaemia, and that its effect was not apparently due to vitamin B₁₂ from a 5-g portion of fresh liver.
Experiments have been carried out to see whether promin-induced anaemia be alleviated by administration of folic acid. The interrelationships between folic acid, vitamin B₁₂ and a purified liver fraction have also been studied. The results obtained can be summarized as follows:
1. Folic acid was not effective when administered, whether orally or injected, at a 10-mg level per 100g body-weight of albino rat (Fig. 1).
2. The purified liver fraction at its ineffective level, i.e., a 40-mg level (equivalent to 2.0g fresh liver) showed a marked effect when supplemented with 1.5mg of folic acid. A combination of a 1.5-microgram level of vitamin B₁₂ with 1.5mg of folic acid was somwhat effective, though each level alone has been confirmed to be ineffective (Fig. 2).
3. Data presented here suggest that the purified fraction of whale liver contains apparently an unidentified antianaemic factor which is responsible for alleviating the promin-induced anaemia.