抄録
In the present work the spectrum and the mode of action of the antibiotic autoxidizcd calamary oil and the reversal of inhibitory action of it were investigated, and the following results were obtained.
1) The autoxidized calamary oil inhibits the growth of bacteria independently of their Gramstaining characters, and it shows weak antibiotic activity on molds and some strains of yeasts and Fungi imperfecti.
2) The antibiotic action of the autoxidized calamary oil causes the prolongation of the lag period and is effective when added at the beginning of culture, while the autoxidized calamary oil stimulates the growth of organisms in certain cases when added at the stationary period.
3) The antibiotic action of the autoxidized calamary oil is not reversed by sulfhydryl compouds and surface active substances such as cholesterol, lecithin and α-tocopherol; but it is reversed by unsaponifiable matter of plant oil, medicinal yeast and among tested adsorbents only by activated charcoal.
4) It seemed that the antibiotic action of the autoxidized calamasy oil depended on an oxidative product, whose mode of action differed from those of unsaturated fatty acids, saturated fatty acids and surface active substances.
