コイの脂質過酸化物の吸収におよぼすビタミンEおよびエトキシキンの影響について

抄録

The effect of antioxidants on the absorption of lipid hydroperoxide in carp, Cyprinus carpio has been studied.
The carp were divided into four groups. Group 3 was given synthetic diet with vitamin E (dl-α-tocopheryl acetate), Group 4 the diet with ethoxyquin (6-ethoxy-1, 2-dihydro-2, 2, 4-trimethylquinoline) and the others synthetic diet only.
After they were fed on these diets for two weeks, the following ¹⁴C-labelled compounds were administered by polyethylene catheter.
Group 1: 1-¹⁴C-methyl linoleate (1-¹⁴C-ML)
Group 2: purified 1-¹⁴C-methyl linoleate hydroperoxide, POV 5960meq/kg (1-¹⁴C-MLHP)
Group 3: 1-¹⁴C-MLHP plus vitamin E
Group 4: 1-¹⁴C-MLHP plus ethoxyquin
After 24 hours, all the fish were killed. The distribution of radioactivity in various tissues was compared among the four groups.
The results are summarized as follows:
1) The carp absorbed little hydroperoxide of methyl linoleate.
2) The distribution of radioactivity in Group 3 was about the same as that in the control (Group 1). It is suggested therefore that vitamin E may act as a peroxide decomposer and stabilizing factor of intestinal epithelium.
3) Since the radioactivity in Group 4 was negligible, ethoxyquin was not effective for absorption of hydroperoxide in vivo.