抄録
Although subcutaneous (SQ) and intra-abdominal (IP) implantation of telemetry device are the most common technique in primates, adverse events such as skin erosion/swelling in SQ and organ damage in IP are often reported in this species. Body temperature (BT) is one of the parameter collected by the telemetry device, but it has generally been considered that true body temperature can be collected only through the IP implant in primates. Because of several adverse effects seen in SQ technique, we have investigated intermuscular approach (IM) to see if this can be used as alternate surgical method and if true body temperature can be collected. With the animals anesthetized with isoflurane, a transmitter was implanted between the abdominus rectus and lattisimus dorsi muscles approximately on 30 cynomolgus monkeys. Compared to SQ technique, recovery time was shorter and we have not seen any complications. This poster presents normal physiological range of HR/BT collected for 3 days continuously and comparison of normal variation of HR/BT among different origin of monkeys; Indonesia, China, and Cambodia via IM technique. Also compound X was administered as positive control and dose related increased HR/BT were observed.
Based on our experience and HR/BT data, IM implantation in primates is superior to SQ/IP approach because of no few post surgical complications, fast recovery time, and capability of true body temperature collection.
