Comparison of toxic effect of Na salicylate by oral and intravenous administration in cynomolgus monkeys

抄録

Toxicity of Na salicylate was compared by oral or IV route in cynomolgus monkeys. Three males and females were orally treated with escalating three dosages with a recovery period of 7 days; 500, 750, 1125 mg/kg. For IV route, 12 males and 12 females (3 animals per group) were treated with 3 dosages; 0 mg/kg, 138 mg/kg, 275 mg/kg, 550 mg/kg, respectively. The findings were as follows: oral emetic dose was between 500 mg/kg and 750 mg/kg, showing more than 750 mg/kg dosage did not show any clinical sign except vomiting. The IV emetic dose was about 275 mg/kg, and the approximate lethal dose for IV route was between 275 mg/kg and 500 mg/kg.