抄録
As it was found that the industrial patients poisoned with trichloroethylene showed thiamine deficiency, the author carried out experiments using animals to observe the relationship between the exposure to trichloroethylene and the thiamine metabolism. In animals exposed to trichloroethylene, the loss of body weight, decrease in the total thiamine concentration in blood, and acute and marked drop of urinary excretion of thiamine were recognized. In animals loaded with thiamine the rate of thiamine excretion was found to decrease. From these findings it was concluded that trichloroethylene exposure caused disturbances of thiamine metabolism. The gain of liver weight and pathological changes of the heart, liver, kidney and adrenal body were also observed.
