巻号一覧
18 巻
選択された号の論文の325件中1～50を表示しています
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川崎 近太郎原稿種別: 本文
1959 年 18 巻 p. 1-9
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 9-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 9-
発行日: 1959年
公開日: 2017/12/22
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勝井 五一郎, 三枝 礼子原稿種別: 本文
1959 年 18 巻 p. 10-15
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーThe present study is concerning a experimental investigation of the conditions in making vitamin A aldehyde from natural vitamin A oil. MnO_2 was employed in the process of oxidation of vitamin A alcohol, and the optimal raito of MnO_2 to vitamin A alcohol used in this reaction was found to be 20 : 1. No vitamin A aldehyde was produced in case of a lower raito of MnO_2 to vitamin A alcohol and the yield of vitamin A aldehyde showed to be not so higher in a higher raito of MnO_2 to vitamin A alcohol. No significant correlation was found between concentration of vitamin A alcohol treated with MnO_2 and yield of vitamin A aldehyde, although it was demonstrated that 1-2% concentration or vitamin A alcohol were suitable for the reaction. The optimum reaction temperature was indicated to be 20-25℃, and it was demonstrated that the reaction velocity increased at the reaction temperature of near to 30℃, but the yield decreased under the condition of such temperature. It was also demonstrated that the reaction does not readily go on in a lower temperature than in the optimum temperature. The maximum yield of vitamin A aldehyde was obtained within 5-10 days under conditions of 1-2% concentration of vitamin A alcohol, about 20℃ of the reaction temperature, and 20 : 1 in the raito of MnO_2 to vitamin A alcohol, having showed to be as high as 60-70%.抄録全体を表示PDF形式でダウンロード (403K) -
寺田 治, 大石 一雄, 木下 祝郎原稿種別: 本文
1959 年 18 巻 p. 16-20
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーSome fundamental investigations were made on the vitamin B_<12> fermentation with Streptomyces olivaceus. Vitamin B_<12> formation was completed after 3 days, after which the vitamin began to liberate and substantially all was liberated after 7 days. Thirty ml. per flask in rotary shaker or 15 ml. per tube in test tube shaker, each corresponding to oxygen absorption rate 0.7,was found desirable for normal fermentation. No improvement was made with increased sugar concentration or feeding. Three times as much vitamin B_<12> was formed by the addition of from 1 to 200 ppm of CoCl_2・6aq., but 200 or 500 ppm delayed initial growth, and 500 ppm lowered vitamin B_<12> formation. No appreciable effect was observed by inoculum size. The original culture was found to be fairly uniform with respect to vitamin B_<12> productivity.抄録全体を表示PDF形式でダウンロード (538K) -
寺田 治, 大石 一雄, 木下 祝郎原稿種別: 本文
1959 年 18 巻 p. 21-27
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーThe improvements of culture media were undertaken for higher vitamin B_<12> production. After some preliminary experiments the medium proposed by Hall of NRRL was adopted as the basic type and some modifications were made on it. No nitrogen sources more potent than SVP were found. Maltose and lactose were found to be the most potent carbon sources when applied singly, and the combination of glucose and lactose gave the highest result. The elongation of fermentation period and increased vitamin B_<12> production were observed with the addition of lactose. The best medium obtained was No. 47 on which the yield of the vitamin higher than 7.0μg/ml were obtained.抄録全体を表示PDF形式でダウンロード (694K) -
高田原稿種別: 本文
1959 年 18 巻 p. 27-
発行日: 1959年
公開日: 2017/12/22
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寺田 治, 大石 一雄, 木下 祝郎原稿種別: 本文
1959 年 18 巻 p. 28-33
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーFurther experiments were conducted for higher vitamin B_<12> production by the improvements of culture media. Supplementations to media with various compounds including o-phenylenediamine, proline, cyanides, chlorophyllin and plant hormones failed to induce a stimulation of vitamin B_<12> production. Maltose which had been shown previously to be the most potent carbon source when used singly was found less active than lactose when used in combination with glucose. Addition of SVP more than 6% resulted in a reduced the vitamin production. It was found that the enrichement of media with lactose induced an abundant mycelial growth, but the abundance did not necessarily mean an increased vitamin B_<12> production. The highest yield obtained was 8.5μg/ml after 12 days fermentation.抄録全体を表示PDF形式でダウンロード (606K) -
高田原稿種別: 本文
1959 年 18 巻 p. 33-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 33-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 33-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 33-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 33-
発行日: 1959年
公開日: 2017/12/22
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石原 紀臣原稿種別: 本文
1959 年 18 巻 p. 34-44
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーResearches have been done for testing the function of adrenal cortex with vitamin B_6 deficient rats. The corticoid content of blood was determined by Sweet-Takeda's method and the adrenal tissue was examined histochemically. It was shown that the adrenal function was lowered by the vitamin B_6 deficiency and the more the dificiency pronounced, the more the degeneration of adrenal cortex was remarkable. It is already known that the pituitary-adrenal cortex system is controlled by the central nervous system, but in the author's experiments, it was confirmed that the supply of ACTH was able to restore the drawback of pituitary, but not the failure of adrenal cortex. Thus the author supposed that the failure of adrenal function was partly due to the defect in peripheral production of cortex hormone.抄録全体を表示PDF形式でダウンロード (2034K) -
則武 重雄原稿種別: 本文
1959 年 18 巻 p. 45-57
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーThe effects of injection of cocarboxylase or adenosinetriphosphate upon the myocardial metabolism in experimental coronary insufficiency were studied on 55 dogs. (1) The use by myocardia of pyruvate, lactate, α-ketoglutaric acid, inorganic phosphate, potassium and magnesium decreased gradually after thoracotomy. (2) The metabolic change due to the experimental coronary insufficiency was more significant, so that the myocardial use of these compounds markedly decreased or became negative. (3) After the injection of cocarboxylase or adenosinetriphosphate the myocardial use of these compounds increased for some time. From the above results, it seems true that cocarboxylase and adenosinetriphosphate are able to restore the disturbances in myocardial metabolism induced by myocardial hypoxia.抄録全体を表示PDF形式でダウンロード (1390K) -
川崎 近太郎, 須原 喬, 入谷 信子原稿種別: 本文
1959 年 18 巻 p. 58-62
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーAs the amount of thiamine absorbed from intestinal tracts is only limited one and much of thiamine is excreted into feces, we tried to find out active agents to promote intestinal absorption of thiamine with their simultaneous oral administration by measuring the increase of urinary thiamine excretion. Ten mg of sodium oleyl methyl taurate (OMT) orally given to rats with 5 mg of thiamine stimulated their urinary thiamine excretion ; 0.85 mg of thiamine were found in 24-hour urine while 0.20 mg of thiamine in case of thiamine alone administrated. 30 mg of OMT with 5 mg of thiamine showed about sevenfold increase of the urinary thiamine in 24 hours (e. g. 1.43 mg). Thiamine in feces was decreased as the amount of OMT given was increased. No effect was observed with Tween 60,Span 20,CMC, sodium alginate, powdered bile, lecithin, Aerosol OT, sodium cholate or sodium taurocholate.抄録全体を表示PDF形式でダウンロード (555K) -
高田原稿種別: 本文
1959 年 18 巻 p. 62-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 62-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 62-
発行日: 1959年
公開日: 2017/12/22
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須原 喬, 入谷 信子原稿種別: 本文
1959 年 18 巻 p. 63-66
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーThiothiamine might be oxidized to thiamine in animal bodies coupled with any other biological oxidation. Therefore preventive tests of thiothiamine against thiamine deficiency on the simultaneous administration of cysteine, sodium thioglycollate, FAD, ascorbic acid or menadione were made with young rats. Ten μg of thiothiamine per day with any of them did not prevent thiamine deficiency : all animals lost weights after 2 or 3 weeks. Daily dose of 50μg thiothiamine alone showed no further growth, although a few animals were able to maintain their slow growth. Simultaneous administration of each of the compounds with thiothiamine was proved to have no appreciable synergistic effect for weight-gain of the animals compared to the response curve of daily 5μg doses of thiamine.抄録全体を表示PDF形式でダウンロード (365K) -
高田原稿種別: 本文
1959 年 18 巻 p. 66-
発行日: 1959年
公開日: 2017/12/22
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須原 喬, 入谷 信子原稿種別: 本文
1959 年 18 巻 p. 67-71
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーIn the previous test, we found slight weight gains in some of albino rats at daily doses 50μg of thiothiamine with either cysteine or menadione. The authors estimated the amount of thiamine in the liver of these rats and found that it was less than 6μg per animal ; that is abount 1/4-1/10 of that of animals receiving daily 5μg of thiamine alone, and nearly the same as that of thiamine deficient or thiothiamine given animals (daily 50μg). The homogenate of rat liver was proved to have no ability to convert thiothiamine into thiamine even in the presence of menadione or cysteine : the absorption of oxygen was not increased by shaking liver homogenate with thiothiamine for 1.5-2 hours, compared to the homogenate alone. In these experiments the addition of menadione or cysteine did not stimulate the oxygen absorption. Moreover, after menadione or cysteine was previously given to rats for 4 days, their liver homogenate also indicated no additional oxygen uptake with thiothiamine.抄録全体を表示PDF形式でダウンロード (476K) -
高田原稿種別: 本文
1959 年 18 巻 p. 71-
発行日: 1959年
公開日: 2017/12/22
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須原 喬, 入谷 信子原稿種別: 本文
1959 年 18 巻 p. 72-75
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーThough thiothiamine and thiamine are much alike in chemical constitutions, thiothiamine is more easily absorbed from the intestines and its urinary excretion is much more than that of thiamine. Thiamine administered to albino rats on oral doses of 5-50mg, was excreted in the 24 hour urines at the rate of 7-12% to the doses, while thiothiamine showed the excretion of 26-51% to the doses on the similar tests. On the contrary, subcutaneous injection of thiamine in dose of 30mg or 50mg showed its excretion of more than 80% in the urines, while thiothiamine was excreted nearly in the same extent as the oral dosage. Thus it will be reasonably assumed that thiothiamine is more easily permeable through intestinal membranes and the absorbed thiothiamine will be decomposed to a greater extent than thiamine.抄録全体を表示PDF形式でダウンロード (458K) -
高田原稿種別: 本文
1959 年 18 巻 p. 75-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 75-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 75-
発行日: 1959年
公開日: 2017/12/22
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神崎 寛原稿種別: 本文
1959 年 18 巻 p. 76-87
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーOne μc per g of radioactive phosphorus in the form of sodium phosphate was given either by intramuscular injection or by oral administration on vitamin A deficient rats. Thereafter, the amounts of inorganic P, total organic P, phosphoprotein, nucleic acid P and phospholipid in the liver along with radioactivity in each of these fractions were measured with the course of time. The amounts of inorganic P, total organic P, nucleic acid P and phospholipid in the liver of vitamin A deficient rats were not much different as compared to the normal rats. The turnover of radioactive P into inorganic P, total organic P, phosphoprotein and nucleic acid P in the liver of vitamin A deficient rats was substantially the same as the control, whereas the turnover or incorporation of P^<32> into phospholipid during vitamin A deficiency was evidently delayed in comparison with the control, regardless of the method of administration of P^<32>. The delay in P^<32> turnover into phospholipid was quickly recovered by the addition of 5,000 I. U. of vitamin A-palmitate per 100 g of diet. Moreover, the above delay was also proved by the in vitro experiments with homogenized liver tissues.抄録全体を表示PDF形式でダウンロード (1034K) -
高田原稿種別: 本文
1959 年 18 巻 p. 87-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 87-
発行日: 1959年
公開日: 2017/12/22
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藤谷 喜久子, 渡辺 辰也原稿種別: 本文
1959 年 18 巻 p. 88-89
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーAccording to Ulbricht, the methylmercapto-compound referred in the title is said to antagonize to vitamin B_6,espeoially to pyridoxamine in the culture of vitamin B_6 requiring mutant of E. coli or to antagonize to the pyrimidine moiety of thiamine in the culture of a mutant of several bacteria. In this connection the authors attempted to see whether some antagonism exists between the above two compounds also in mice which were injected with the methylmercapto-compound. But no competition was found. The toxicity of the thiomethyl compound was rather weak.抄録全体を表示PDF形式でダウンロード (234K) -
高田原稿種別: 本文
1959 年 18 巻 p. 89-
発行日: 1959年
公開日: 2017/12/22
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堀田 一雄, 杉浦 嘉功, 武野 正弘原稿種別: 本文
1959 年 18 巻 p. 90-91
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーThe D-amino acid oxidase activity of rabbit's retina was lassayed by Warburg's manometric method. The results showed that D-amino acid oxidase was found in retina of rabbit and its activity decreased by the light.抄録全体を表示PDF形式でダウンロード (247K) -
高田原稿種別: 本文
1959 年 18 巻 p. 91-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 91-
発行日: 1959年
公開日: 2017/12/22
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伊藤 鐐太郎原稿種別: 本文
1959 年 18 巻 p. 92-95
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーIn order to study the function of the liver in vitamin A metabolism, the following experiments were made. A definite amount of aqueous emulsion of vitamin A-palmitate was injected into the femoral vein of a healthy dog and the determination of serum vitamin A alcohol and its ester contents of arterial and hepatic venous blood was carried out before injection and 5,30,60 and 120 minutes after injection. The blood was taken out with a liver catheter. A considerable amount of vitamin A ester administered intravenously was taken up in the liver. A part of vitamin A ester taken up into the liver was hydrolyzed to vitamin A alcohol and then returned to blood as free form.抄録全体を表示PDF形式でダウンロード (512K) -
伊藤 鐐太郎原稿種別: 本文
1959 年 18 巻 p. 96-98
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーA definite amount of aqueous emulsion of vitamin A-palmitate was injected into the femoral vein of a dog whose liver had been damaged by CCl_4 and the determination of serum vitamin A alcohol and its ester contents of arterial and hepatic venous blood was carried out before injection and 5,30,60 and 120 minutes after. Intravenously administered vitamin A ester was taken up in the damaged liver more rapidly than in the healthy tissue. The amount of the ester taken in the former was also larger than in the latter. Vitamin A ester taken up in the damaged liver was hardly hydrolyzed to the alcohol form.抄録全体を表示PDF形式でダウンロード (388K) -
伊藤 鐐太郎原稿種別: 本文
1959 年 18 巻 p. 99-104
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーIn order to study the function of the liver for β-carotene, administered, the following experiments were made. Various amounts of aqueous emulsion of β-carotene were injected into the femoral vein of a healthy dog, and the determination of serum carotene, vitamin A alcohol and its ester contents of arterial and hepatic venous blood was done before injection and 5,30,60 and 120 minutes after. A considerable amount of β-carotene administered intravenously was taken up in the liver. A part of β-carotene taken up in the liver was chiefly converted to vitamin A ester and a much smaller amount of vitamin A alcohol was also detected. The formed vitamin A ester was transferred into blood. Serum carotene and vitamin A contents of children with hepatic disorders were determined. The results showed that conversion of carotene to vitamin A was inhibited in some cases as a result of hepatic disorders.抄録全体を表示PDF形式でダウンロード (669K) -
伊藤 鐐太郎原稿種別: 本文
1959 年 18 巻 p. 104-106
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーA definite amount of aqueous emulsion of β-carotene was injected into the femoral vein of a dog whose liver had been damaged by CCl_4,and the determination of serum carotene, vitamin A alcohol and its ester contents of arterial and hepatic venous blood was made before injection and 5,30,60 and 120 minutes after. The amount of β-carotene taken up into the damaged liver was larger than that in the healthy tissue. Carotene taken up into the demaged liver was hardly converted to vitamin A.抄録全体を表示PDF形式でダウンロード (402K) -
伊藤 鐐太郎原稿種別: 本文
1959 年 18 巻 p. 107-112
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーIn order to study effect of α-tocopherol upon the conversion of β-carotene to vitamin A in the liver, the following experiments were made. Various amounts of aqueous emulsion of α-tocopherol, α-tocopheryl acetate and a definite amount of β-carotene were injected into the femoral vein of a healthy dog, and the determination of serum carotene, vitamin A alcohol and its ester contents of arterial and hepatic venous blood was made, before injection and 5,30,60 and 120 minutes after. A small dose of α-tocopherol stimulated β-carotene uptake in the liver and its conversion to vitamin A in the tissue. A large dose of α-tocopherol stimulated β-carotene uptake in the liver, while it had no effect upon the conversion to vitamin A. A large dose of α-tocopheryl acetate also stimulated β-carotene uptake in the liver, but inhibited the conversion to vitamin A.抄録全体を表示PDF形式でダウンロード (710K) -
高田原稿種別: 本文
1959 年 18 巻 p. 112-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 112-
発行日: 1959年
公開日: 2017/12/22
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大嶋 竹一原稿種別: 本文
1959 年 18 巻 p. 113-115
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーStudies were made on pyruvate-oxidase activity in thiamine deficient rats. The enzymatic activity was estimated by measuring the volume of O_2 taken up into a washed liver homogenate. Effects of addition of thiamine diphosphate, DPN, CoA, lipoic acid, ATP, nicotinamide, cytochrome c, glutathione and vitamin B_<12> in various combinations were also examined. Qo_2 (N) value of the enzymatic system was remarkably lower in the deficient rats than in the control. The oxidase in the deficient rats was not activated by the cofactors described above. These results suggest that the low activity of pyruvate-oxidase in thiamine deficient rats is not due to the deficiency of the vitamin as an coenzyme, but rather to insufficient synthesis of the apoenzyme.抄録全体を表示PDF形式でダウンロード (350K) -
広瀬 幸男原稿種別: 本文
1959 年 18 巻 p. 116-129
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーThiamine deficiency was produced in mice experimentally on 19 kinds of casein and rice diet which contained various amounts of lysine, methionine and valine. The appearance of clinical signs of thiamine deficiency in mice on the hair, feet, cramp and growth was observed in all groups. The thiamine deficiency appeared earlier in groups fed on rice diet than those on casein diet in spite of the same ratio of protein and carbohydrate in these diets. Addition of lysine, methionine and valine to the rice diet improved the growth and delayed the occurrence of the thiamine deficiency symptoms. The effects were remarkable, especially in the case of lysine and methionine addition. This fact may be an explanation for one of the reasons why thiamine deficiency occurs frequently in people taking rice diet.抄録全体を表示PDF形式でダウンロード (1379K) -
高田原稿種別: 本文
1959 年 18 巻 p. 129-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 129-
発行日: 1959年
公開日: 2017/12/22
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蒲谷 良夫原稿種別: 本文
1959 年 18 巻 p. 130-140
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーStudies were made, using mice, on the change of riboflavin metabolism due to the administration of antibiotics and on the mechanism of appearance of riboflavin deficiency caused by antibiotics. When the animals were fed on a sufficient diet, the growth was rather stimulated by the administration of antibiotics. Antibiotics did not affect on the delayed growth and the change of the bodily appearance caused by riboflavin deficiency or liver damage. By the administration of antibiotics, the amount of riboflavin and its ester ratio of each organ decreased, especially in the case of riboflavin deficiency or liver damage. Riboflavin deficiency caused by antibiotics might not only be due to the decrease of riboflavin content, but to the disturbance of riboflavin utilization, shch as that of phosphorylation, especially in liver damage. However, the real causes for riboflavin deficiency might be much complicated.抄録全体を表示PDF形式でダウンロード (1313K) -
高田原稿種別: 本文
1959 年 18 巻 p. 140-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 140-
発行日: 1959年
公開日: 2017/12/22
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高田原稿種別: 本文
1959 年 18 巻 p. 140-
発行日: 1959年
公開日: 2017/12/22
ジャーナル フリーPDF形式でダウンロード (146K)