抄録
Blood thiamine level elevated by the intravenous injection of TATD was higher and maintained longer in blood than when thiamine was administered. This was ascribed to prominent distribution and to a higher accumulation of free thiamine in blood cells, in contrast with thiamine administration. This characteristic was also observed in a washed blood cell suspension system in vitro. In spite of such an unique behaviour of thiamine moiety of TATD it was found that lipoate moiety was not accumulated in blood cell. Lipoic acid itself was not also concentrated in blood cell. The difference between behaviour of thiamine moiety and of lipoate moiety of TATD towards blood cell is discussed.
