抄録
Ariboflavinosis caused by the administration of chlortetracycline was studied by using albino rats. Body weight gain and flavin content of the liver and kidney of the animals were measured with 7 groups of animals : (1) riboflavin-deficient diet, (2) 10 μg of riboflavin, (3) riboflavin-deficient diet plus chlortetracycline 5 mg per day for a rat, (4) riboflavin 2 μg plus chlortetracycline 5 mg per day for a rat, (5) riboflavin 2 μg plus chlortetracycline 10 mg per day for a rat, (6) riboflavin 5 μg plus chlortetracycline 10mg per day for a rat, and (7) riboflavin 10 μg plus chlortetracycline 10 mg per day for a rat. The results showed that chlortetracycline promotes the appearance of ariboflavinosis. As to the cause of ariboflavinosis, riboflavin and chlortetracycline act in competition with each other. This may be explained, at least partly, by the previously reported fact that chlortetracycline forms a complex with riboflavin and inhibits flavin enzyme in competition with the coenzyme FAD as studied by using D-amino acid oxidase.
