抄録
Recently, there is a tendency to use successively of a large amount of thiamine. The author studied whether an administration of excessive amount of thiamine have ill effect or not. No harmful effect was observed when 0.5-1mg of thiamine was injected subcutaneously for 90 days on rat. However, an administration of 0.5mg of thiamine for pyridoxine-deficient rat caused somewhat depression of body weight, compared with that of pyridoxine deficiency without thiamine. It was also revealed that a large amount of thiamine accelerates the running fit caused by oxymethylpyrimidine for rat or mouse. These results suggest that excess dosage of thiamine promotes the pyridoxine deficiency.
