抄録
In order to investigate the influence of homopantothenic acid (HOPA) on the ultrastructure of liver cells of young rats, fed on pantothenic acid (PaA)-deficient diet, was administered with HOPA at a daily dose of 1g/kg for 4 days (group 1) and compaired with rats supplemented by PaA (group 2). In group 1,the hepatic cells were atrophied and appeared to be somewhat dark, as "shrivelled necrosis". The cytoplasmic organelles were increased in number and looked compact lacking the cytoplasmic matrix. The mitochondrion was increased in number and size, and showed a curious deformity. The outer membrane showed a toothed-wheel structure and the cristae appeared a wheel-axle pattern. The microbody was increased in number with bizarre figure. The crystalloid in the matrix was disappeared. Rough surfaced endoplasmic reticulum (RER) was almost disappeared and the cisterna of the RER appeared to break up into small units. The RER was tended to be less frequently coated by ribosomes. The smooth surfaced reticulum was partially absent and glycogen particles were lacking completely in most cells. In some cells, the cytoplasmic matrix was tightly packed with the increased number of mitochondria and microbodies. In group 2,the change of the hepatic cells was less prominent than in group 1.
