抄録
Daily administration of 300mg/kg of latamoxef to rats fed a vitamin K deficient diet from 7 days to 9 days induced severe hypoprothrombinemia. The extrinsic and intrinsic coagulation activities in the latamoxef treated rats were decreased in higher degree than those in the rats fed a vitamin K deficient diet alone. Single oral administration of 0.1 or 1mg/kg of vitamin K_2 to the hypoprothrombinemic rats improved their coagulation activity. The coagulation activity was normalized completely by oral administration of 0.1mg/kg vitamin K_2 once a day for 2 days. These results suggest that latamoxef aggravates vitamin K deficiency and causes severe hypoprothrombinemia.
