抄録
The methylation of pyrazine with methanol was carried out in the presence of Ni catalysts. Raney Ni was found to have an excellent activity for the methylation and 2-methylpyrazine was formed as a main product, with a small amount of dimethylpyrazine. By use of Raney Ni at 200°for 12hr, the yields of 2-methylpyrazine and dimethylpyrazine were 49.2 and 9.3%, respectively. Pyridine was also methylated with Raney Ni in good yield. The activity of several types of Ni catalysts was examined in the methylation of pyrazine.
