ステロイドホルモン剤の血液性状に対する影響と漢方方剤の改善作用及び作用成分(第5報) : Betamethasone連用ラットに対する小柴胡湯, 大柴胡湯, 三黄瀉心湯とClofibric Acidの作用の比較

抄録

Effects of clofibric acid and three kampo-prescription, sho-saiko-to, dai-saiko-to and san-oh-shashin-to on biological responses in betamethasone treated rats were compared especially from hemorheological view points. Dai-saiko-to and san-oh-shashin-to, famous kampo-prescriptions used in traditional Chinese system of medicine, were found to improve the hyperviscosity accompanied with hyperlipemia and hypercoagulative property affected by betamethasone treatment. The activities of clofibric acid which has also improved hyperviscosity and three kampo-prescriptions were found to differ in degree of reacting on serum levels of corticosterone, lipidoperoxide and triglyceride and liver weight in betamethasone treated rats.