Vitamin B₁及び諸関係化合物の研究 (第11報)

Thiazolium化合体の新合成法について (其の2)

抄録

2-Alkyl-4-amino-5-formaminomethylpyrimidine hydrochloride, α-halogen ketones and H₂S were condensed at 110-120° in anhydrous formic acid as a solvent, and following were synthesized: 4-Methyl-5-β-hydroxyethyl-N-(2′-ethyl-4′-aminopyrimidyl-5′)-, 4-methyl-5-β-hydroxyethyl-N-(2′-benzyl-4′-aminopyrimidyl-5′)-, 4-methyl-5-ethyl-N-(2′-methyl-4′-aminopyrimidyl-5′)-, 4-methyl-5-phenyl-N-(2′-methyl-4′-aminopyrimidyl-5′)-, 4-methyl-5-carboxy-N-(2′-methyl-4′-aminopyrimidyl-5′)-, and 4-methyl-5-carbethoxymethyl-N-(2′-methyl-4′-aminopyrimidyl-5′)-methylthiazolium chloride hydrochloride. However, the yields of compounds other than the first two were very poor. This fact is interesting in connection with physical synthesis of vitamin B₁ inside the body.