クマリン誘導体の薬品的研究 (第4報)
駆虫作用に就いて その2
1953 年 73 巻 2 号 p. 107-110
詳細
1953 年 73 巻 2 号 p. 107-110
Eight kinds of coumarin derivatives were prepared, their anthelmintic action determined, and following relationships were found to exist between their chemical structure and anthelmintic action.
1) No outward change occurred on the addition of arabic gum and Tween 80 to the modified Locke-Ringer solution.
2) The action of coumarin was slightly different in the Locke-Ringer modified solution and in the Bunge solution.
3) The anthelmintic action decreased when the double bond between 3- and 4-positions of coumarin, 2-thiocoumarin, and 4-methylcoumarin were hydrogenated to their respective dihydro compounds.
4) No anthelmintic effects were found in ethyl coumarin-3-acetate, methyl isocoumarin-3-carboxylate, and ethyl coumalin-5-carboxylate, but a good effect was found in methyl coumalin-5-carboxylate.
5) There seemed to be no relation between hypnotic and anthelmintic action although both coumarin-3-carboxylic diethylamide and soluble barbital excited the ascaris.
6) It seemed that the compounds melting between 70° and 100° possessed comparatively good efficacy.
