抄録
Heating of triethanolamine hydrochloride at 200° for three hours afforded β-4-morpholinoethanol in 50% yield but the difference in the reaction temperature and duration results in the formation of morpholine, 1, 2-dimorpholinoethane, 2, 2′-dimorpholinediethyl ether, and piperazine. Heating of triethanolamine with the hydrochloride of mono-, di-, or trialkylamine at 250° invariably affords N-alkylpiperazine in approximately 30% yield, with about 15% of morpholine as a by-product. Vapor phase reaction of ethylene glycol and ammonia, with silica-alumina catalyst, failed to form piperazine and morpholine, and only a small amount of α- and γ-picoline were detected.
