非バルビツレート静脈麻酔剤の研究 (第1報)
N, N-Diethyl-2-(2-methoxy-4-allylphenoxy) acetamide誘導体の合成
1962 年 82 巻 3 号 p. 356-363
詳細
1962 年 82 巻 3 号 p. 356-363
Some experimental pharmacological observations were made on N, N-diethyl-2-(2-methoxy-4-allylphenoxy) acetamide as an anesthetic. Its anesthetic effect lasts only a short time and there are some respiratory stimulative and analeptic effect on the cardiovascular system. There is no cumulative action with average clinical dose and N, N-diethyl-2-(2-methoxy-4-allylphenoxy) acetamide is a true, very short-acting agent. On the other hand, it is hardly soluble in water, produces some irritation on the vein wall, and has a very little analgesic action.
Thirty-four kinds of 2, 4-disubstituted phenoxy compounds were prepared to clarify the relationship between chemical structure and anesthetic effect of N, N-diethyl-2-(2-methoxy-4-allylphenoxy) acetamide derivates.
