抄録
As a part of synthesis of actinomycine-like polypeptides, attempt was made to synthesize polypeptides by substitution of the 1-phenazinecarboxylic acid, the parent skeleton of these antibiotics, with phenoxazine, and dipeptides and tripeptides of several kinds of amino acid were prepared. N-(1-Phenazinylcarbonyl)glycine and its ethyl ester, N-(1-phenazinylcarbonyl)-DL-alanine, -DL-valine, -DL-leucine, -DL-norvahne, -DL-norleucine, and -DL-phenylalanine were obtained by the Schotten-Baumann reaction. By the azide method using N-(1-phenazinylcarbonyl)glycine ethyl ester, N-[N-(1-phenazinylcarbonyl)glycyl]-DL-alanine methyl ester and methyl N-[N-(1-phenazinylcarbonyl)glycyl]-DL-2-aminobutyrate were obtained. As a hydroxyamino acid derivative, N-[N-(1-phenazinylcarbonyl)glycyl]-DL-serine methyl ester was obtained by the use of N, N′-dicyclohexylcarbodiimide.
