Keteneおよびその誘導体の研究(第23報) : Diketeneとα-アミノ酸との反応

抄録

An investigation was made on the reaction between diketene and various α-amino acids such as glycine, alanine, leucine, phenylalanine, tyrosine, 3, 5-dibromotyrosine and pipecolinic acid and so on. In the reactions with free amino acids, substituents adjacent to a nitrogen atom gave an influence and any pyridone type of compounds (IV) was not prepared except glycine and alanine. The reaction with ethyl ester of these amino acids afforded tetramic acid (III) synthetically. The reaction with aryl N-acetoacetylglycinate did not afford any expected pyridone type of compounds (IV), and intramolecular dehyrated compound (IX).