抗うつ剤としてのDidenzo[b, e][1,4]diazepine誘導体の合成
1969 年 89 巻 2 号 p. 158-163
詳細
1969 年 89 巻 2 号 p. 158-163
On the basis of earlier finding that an alkylsulfonyl group when introduced into simple benzene derivatives exerted a CNS activity, ethylsulfonyl derivatives of dibenzo [b, e]-[1, 4] diazepines (VII, VIII, and X) were synthesized. A dimethylsulfamyl derivative (XX) was also prepared for comparison. VII (R=CH3, n=2) was selected as a potent anti-depressant with low toxicity.
