複素環式化合物の合成研究(第307報) : 3-Phenyl-1,5-trimethylenepyrazoleの合成
1969 年 89 巻 4 号 p. 583-585
詳細
1969 年 89 巻 4 号 p. 583-585
Claisen condensation of acetophenone with γ-butyrolactone in the presence of sodium ethoxide afforded 1-hydroxy-6-phenylhexane-4, 6-dione (III), which was treated with 80% hydrazine hydrate to give 3-phenyl-5-(3-hydroxypropyl)pyrazole (IV). Cyclization of IV with phosphoryl chloride or 48% hydrobromic acid gave 3-phenyl-1, 5-trimethylenepyrazole (II), one of the isomers of withasomnine.
