抄録
1-(m-Chlorophenylpropyl) -6, 7-dimethoxy -1, 2, 3, 4-tetrahydro-isoquinoline (III) was synthesized in order to examine whether this compound would be effective as a muscle relaxant or not. 3-Chlorobutyric acid (IX), which was obtained from m-chlorophenyl-propionic acid (IV) via 3-chlorophenylpropanol (VI), the corresponding chloride (VII) and cyanide (VIII), was converted into the amide (XI) and the Bischler-Napieralski reaction of XI, followed by reduction of its product, gave 1, 2, 3, 4-tetrahydroisoquinoline (III). Further, the reaction of 1, 2, 3, 4-tetrahydroisoquinoline (III) with sodium amide in liquid ammonia was also investigated.
