抄録
The follwing data have been obtained on antiatherosclerotic activity of 1, 3-propanediol bis(2-p-chlorophenoxyisobutyrate)(CLY-503) compared with ethyl 2-p-chlorophenoxyisobutyrate (clofibrate). Hypolipidemic activity of CLY-503 was more durable in rats, and more potent in rats and cholesterol -fed mice than clofibrate in continued administration. Cholesterol and triglyceride levels decreased and phospholipid levels were unchanged or increased a little in liver of rats treated with CLY-503 or clofibrate. While lipid levels were not decreased, antiatherosclerotic activity was pronounced in cholesterol-fed rabbits treated with either of these agents. Furthermore, depression of capillary vascular permeability in mice and activation of fibrinolytic activity in rats. were recognized in both agents. However, stabilization of erythrocyte membrane of rats and inhibition of platelet aggregation of rabbits, considered as antiatherosclerotic factors other than lipids concerned, were especially noted in CLY-503.
