抄録
Reaction of thiol-type thiamine sodium salt (I) with dialkylaminosulfenyl halides, sodium dialkylaminothiosulfate or sodium dialkylaminosulfenylthiosulfate gave N-[(4-amino-2-methyl-5-pyrimidinyl) methyl]-N-[4-hydrxy-1-methyl-2-(dialkylaminodithio)-1-butenyl] formamides (II) (thiamine dialkylamino disulfides) in a good yield. Treatment of II with amines was studied and discussed. II showed full thiamine activity in growth-promoting assay using thiamine-deficient rats.
