YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
インドール誘導体の研究(第18報)インドキシル誘導体の合成 その4 1-Acetyl-3-indolinoneとN-Bismethylthiomethylenebenzene-sulfonamide類との反応, およびその生成体と求核試薬類との反応
富永 義則夏木 令子松田 芳郎小林 五郎
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1973 年 93 巻 8 号 p. 971-976

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1-Acetyl-3-indolinone was reacted with N-bis(methylthio)methylenebenzenesulfonamides in the presence of a base and it was found that the reaction differed accodring to reaction conditions. Reaction of 3-indolinone derivative (V, VII) with nucleophilic reagents such as amines and active methylenes afforded substitution products corresponding to the reagent used. By the use of these products, indole-condensed ring compounds, 1-(p-toluenesulfonylamino)-9-(p-toluenesulfonyloxy)pyrazino[1, 2-a]indole (IX) and 1-(p-toluenesulfonylamino)-3H-pyrrolo[1, 2-a]indol-3-one (XI), were synthesized.

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