Amidinohydrazone類の抗菌性(第1報)Alkoxybenzalacetone Amidinohydrazoneの抗菌性

抄録

The relationship between the chemical structure and antibacterial activity of alkoxybenzalacetone amidinohydrazones was studied. These compounds showed a maximum antibacterial activity with the 4-6 carbon atoms in the alkoxyl group. The position of alkoxyl group and substitution of H in the α-position with CH₃ in benzalacetone moiety have no effect on the antibacterial activity. On the substitution of amidino moiety, the antibacterial potency generally decreased in the order of -NH₂, -[chemical formula], and -[chemical formula]. The activities of these compounds against gram-positive bacteria, gram-negative bacteria and fungi decreased in this order.