抄録
4-(2-Methoxycarbonylanilino)-2-chloro-5-nitropyrimidine derivatives (IIIa-c) were prepared from methyl anthranilate derivatives (1a-c) and 2, 4-dichloro-5-nitropyrimidine. Aminopyrimidines (IVa-c) were prepared by the reduction of nitropyrimidines (IIIa-c) with stannous chloride in acetic acid. 2-Chloro-11H-pyrimido [4, 5-b] [1, 4] benzodiazepin-6 (5H)-one derivatives (Va-c) were synthesized by the intramolecular ring closure of aminopyrimidine derivatives. 2-Chloro-11-methylpyrimido [4, 5-b] [1, 4] benzodiazepin-6 (5H)-one (Vd) was obtained by the reductive cyclization of 4-(2-methoxycarbonyl-N-methylanilino)-2-chloro-5-nitropyrimidine (IIId) with stannous chloride in acetic acid.
