As a minimal cell model, a self-reproducing compartment made of membrane molecules, containing a metabolic reac-tion network and informational substances, is proposed. When a precursor of the membrane molecule was added to an aqueous dispersion of giant vesicles, the precursor was converted to the membrane molecule within the vesicular mem-brane containing a catalyst. As a result, the vesicles got corpulent and self-divided, increasing the number of giant vesi-cles. Besides, if the vesicle contained an informational amphiphile with an oligonuleotide head, a polymerization en-zyme, and a template DNA, etc., polymerization of DNA took place on the inner surface of the giant vesicle. This self-reproducing vesicular system is expected to give an excellent clue to understand the origin of life in terms of a con-structive approach.
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