The writer studied the influence of protein-eliminated extract from spleen upon rabbit's blood pressure and pulse systematically, over a long period, by means of the bloodless method. The extract was made in such a condition that 1cc corresponded to 10gr of the raw organ. 1) No changes worth noting were observed by intravenous injection of 0.1cc per kg in blood pressure, pulse curve amplitude and pulse rate. 2) By intravenous injection of 0.25cc per kg, changes were found in blood pressure, and pulse curve amplitude. 3) By intravenous injection of 0.5 cc per kg relatively remarkable changes were produced. Maximal blood pressure fell by 25 mm Hg on the average immediately after injection, and then in one or two cases ascended a little, but in 60 minutes descended by 25 mmHg on the average compared with the original value. The degree of the change in minimal pressure was small compared with that of maximal pressure. Pulse curve amplitude decreased by 2.4 mm on the average immediately after injection, and in 60 minutes decreased by 2.4mm compared with the original value. These changes returned almost to the original values after 24 hours. 4) By subcutaneous injection of 0.5cc per kg, changes were later in appearance and slighter in degree compared with those by intravenous injection. 5) From the above results the author perceives that extract of spleen exerts a depressor effect upon the blood pressure.

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The writer studied the influence of Magnesium Sulfurieum upon Minimal blood pressure, maximal blood pressure, pulse curve amplitude and pulse rate, by means of the bloodless method, and obtained the following results. 1) By intravenous injection of 0.25cc of 10% solution changes worth noting were not observed. 2) By intravenous injection of 0.5cc of 10% solution minimal blood pressure fell by 10mm Hg, maximal blood pressure by 11mm Hg on the average and pulse rate decreased remarkably. By subcutaneous injection of the same quantity no changes were produced. 3) By intravenous injection of 0.5cc of 20% solution, minimal blood pressure fell by 31mm Hg, maximal blood pressure 33 mm Hg on the average and pulse rate decreased remarkably. By subcutaneous injection of the same quantity changes appeared later and were smaller in degree compared with those by intravenous injection. 4) By subcutaneous injection of 0.5cc of 40% solution no remarkable differences compared with those of 20% solution were observed. 5) By intravenous injection of 0.5cc of 10% solution of Magnesium sulfuricum and Glucose were greater and recovery appeared later in comparison with those of 10% solution of Magnesium Sulfuricum. 6) From the above mentioned results the writer can see that Magnesium Sulfuricum caused the minimal blood pressure fall and that this action is increased by adding glucose. I wish to offer my sincere thanks to Prof. T. Mashimo, M. D. for his kind guidauce, and to Subprof. M. Maegawa for his kind advice.

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The author studied the pulsus differens applying a positive pressure on one side of the upper extremities of nomal persons. As for the pulse form, the elastic elevation on the side to which positive pressure was applied became marked in 1〜2 minutes after the beginning of the application of pressure, the incisura became shallow and raised its situation and backstroke elevation became smaller compared with the other side. Such changes of the pulse form aided the degree with progress of time during the application, therefore, the form-difference became marked more and more. After the release of pressure, the above mentioned form-difference was reduced gradually and recoverd to the condition which existed before the application in 3〜5 minutes. As for the amplitude of the pulse curves, the amplitude on the side to which pressure was applied was reduced in all cases during the application. This reduction of amplitude on the applied side appeared in one miuuate and aided the degree more and more in 5〜8 minutes. After the release of pressure, the amplitude-difference which appeared during the application lessened gradually and recovered generally in 3〜8 minutes to the condition which existed before the application. The process of the recovery showed two different forms as follows: in the first group the reduced amplitude of the applied side increased gradually and recovered to the condition which existed before the application, in the second group, the reduced amplitude on the applied side increased and became rather greater than that of the other side after the release of pressure, and thereafter recovered to the condition which existed before the application. Observing such pulsus different because of application of positive pressure, the author believes that the increase of the resistance in the peripheral blood circulation on the applied side must be one of the reasons. Moreover, it is a very interesting fact that the ampitude on the side to which pressure was applid became greater temporarily after the release of pressure than that of the other side, and this fact coincides with the "reactive hyperaemia" theory of Lewis & Grant.

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1) The author studied the working characteristics of the photoelectron counter with changeable cathode, in one atmospheric pressure, changing the cathode substance and the distance between the electric poles. 2) The experiments show that the longer the distance between the electric poles the greater the whole working range and the voltage plateau when we use the same cathode substance. 3) But we are able to have more suitable working characteristics for counting by selecting suitable cathode substances. Namely, it is possible to have greater whole working range and greater voltage plateau with one cathode substance using shorter distance between the electric poles, and consequently lower working voltage than it is with some other cathode substance using longer distance between the electric poles and higher working voltage.

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