Epidemiological and genetic studies were carried out on Japanese and Chinese patients with cleft lip and/or cleft palate (CL/P). The Japanese consisted of 974 propositi who were operated on in the University Dental Hospital Attached to the Faculty of Dentistry, Kyushu University, between 1973 and 1984, plus 7,427 members of the propositi's families. The Chinese consisted of 1,055 propositi who were operated on in the Affiliated Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University, and who had been born before 1980, plus 19,939 members of the propositi's families. The cleft types investigated were cleft lip (CL), cleft lip with cleft palate (CLP), cleft lip with or without cleft palate (CL(P) CL+ CLP), and isolated cleft palate (CP). All types of cleft involving the lip and/or palate were designated as CL/P. The results oatained were as follows:
1) Concerning the type incidence, the Japanese had significantly lower incidence of CL than than the Chinese, while the Japanese had significantly higher incidence of CLP than the Chinese. However, the Japanese and Chinese had almost the same incidence of CL (P) and CP.
2) Concerning the sex difference in the incidence of each type, the in cidence among males was significantly higher than among females for all types with the exception of CP. The percentage of males with CL/P was significantly lower among the Japanese than among the Chinese.
3) Concerning the frequencies of consanguineous marriage in each type, th ere was no significant difference between the Japanese and the Chinese.
4) Concerning the incidence of CL (P) or CP among siblings of propositi where both parents were normal, the Japanese and Chinese had almost the same rate of incidence. Concerning the incidences of CL(P) or CP among siblings of propositi where either one parent or one or more siblings had cleft, the Japanese and Chinse both showed high values. There was some difference, but this was not significant because of the small numbers of cases.
5) The relation of incidence among sibl ings to population frequency suggested that CL (P) and CP were of a multifactorially determined thershold character rather than resulting from a major gene inheritance in both the Japnese and the Chinese.
6) The heritabilities of liability of C L/P for the Japanese were almost the same as those for the Chinese, namely, those of CL(P) for the Japanese and Chinese were 55 % and 53 %, respectively, while those of CL for the Japanese and Chinese were 63 % and 74 %, respectively.
The above results reveal that the Japanese and Chinese are similar to each other, although there are clear differences concerning type incidence and sex difference.
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