In our previous report, the enlargement of the thymus gl and was shown to be noted a high rate in chest radiographs of the cleft lip and palate patients at the age of 3 months. In the current study, further investigation was done in a total of 42 patiets with a particular attention to its change in the following one or two years.
1. In the radiographice xamination performed prior to the cheiloplasty, the thymic enlargement was observed in 32 patients (76.2%) aged 2-5 months. This incidence was more or less similar to that shown in the provious report.
2. In 23 patie nts who underwent palatoplasties at the age between 11 to 21 months, the thymic enlargement was seen in only 34.8%, w hich was significantly lower (p<O.0 5) than its incidence before the cheiloplasty which was as high as 82.6% in the same patients.
3. In the majority o f cases with the enlarged thymu s group, the thymic image occupieda pproximately 60% of the thorax at the 2nd and 4th intercostal spaces, whereas its value in patients with no thymic enlargement was less less than 50%.
4. After the consultation with pediatricians, A CTH (5u/days x 7days) was injected in half of 32 cases with the abnormal thymus before the cheiloplasty and in 3 of 8 cases prior to the palatoplasty. Two patients received its injections prior to the both cheilo and pa. latoplasties. On the other hand, patients with no enlargemeot in the thymus gland prior to the cheiloplasty showed no abnormality in chest radiographs taken before the palatoplasty.
5. Thus, the enlarged thym us gland showed the tendancy to reduce in size with age in cleft lip and palate patients.
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