Aim: The ankle-brachial index(ABI) is an easy-to-use, non-invasive and reliable diagnostic tool for assessing peripheral arterial occlusive disease(PAOD). The CHADS
2(congestive heart failure, hypertension, age ≧75 years, diabetes, prior stroke) score is a simple and popular clinical parameter that is used to assess the risk of stroke in patients with atrial fibrillation(AF). Because all five components of the CHADS
2 score are risk factors for PAOD, the score should have a strong correlation with the presence of PAOD. However, there are limited studies regarding the association between the CHADS
2 score and PAOD in patients without AF. Therefore, the aim of the present study was to investigate whether the CHADS
2 score is positively associated with PAOD in patients without AF.
Methods: A total of 1,320 patients without AF were included in this study. The ABI was measured using an ABI-form device. PAOD was defined as an ABI of <0.9 in either leg.
Results: Among the 1,320 subjects(mean age: 60.3±13.4 years), the prevalence of an ABI of <0.9 was 5.7%. A multivariate analysis showed that an increased age(odds ratio [OR], 1.054;
p<0.001), decreased estimated glomerular filtration rate (OR, 0.971;
p<0.001) and increased CHADS
2 score(OR, 1.861;
p<0.001) were independently associated with an ABI of <0.9.
Conclusions: Our study demonstrated that the CHADS
2 score is significantly associated with an ABI of <0.9 in non-AF patients. Further prospective studies are needed to examine the ability of the CHADS
2 score to predict the incidence of PAOD.
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