This work was designed to clarify the influence of a vitamin D
3 bolus on bone metabolic turnover as manifested by serum osteocalcin, calcium, and other parameters. Bone, like other tissues, in diabetics displays microangiopathy, particularly in the case of type I diabetes. Insulin-dependent diabetics (IDD) without retinopathy (Group I,
n=18), with retinopathy (Group II,
n=16), and healthy persons (Group III,
n=16) were studied. Fasting and 2-h postprandial serum glucose, Ca
2+ (total and ionized), albumin, alkaline phosphatase (ALP), osteocalcin (OC), parathormone (PTH), 25(OH)D
3, 1, 25(OH)
2D
3, and 24-h urinary calcium were evaluated. Diabetics were injected I.M. with 600, 000 IU of vitamin D
3, and were maintained on their dietary and antidiabetic regimen. There was a significant decrease in serum Ca
2+ (total and ionized), urinary calcium, OC, 1, 25(OH)
2D
3 and serum albumin and significant increases in glucose and ALP in both diabetic groups compared with the control. Vitamin D
3 injection in diabetics led to increase in plasma 25(OH)D
3 and 1, 25(OH)
2D
3 and decrease in PTH levels together with normalization of serum Ca
2+ (total and ionized) and 24-h urinary calcium, ALP, and OC. This could be due to the specific action of vitamin D
3. The insignificant difference in calcium levels and its controlling hormones between complicated and uncomplicated diabetics suggests that development of angiopathy neither exaggerates osteopathy nor impairs the osteogenic effect of vitamin D
3. Hepatic and renal metabolism of the latter were intact. Vitamin D
3 injection could ameliorate diabetic hyperglycaemia and improve hypoalbuminaemia.
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