During the past thirteen years, 75 patients (97 limbs) with femoropopliteal occulusive disease due to arteriosclerosis were treated by surgical reconstructions. The 75 patients consisted of 70 men and 5 women with an age range of 32-83 years (mean±SD: 65.9±9.6 years). Regarding the indications for operation, intermittent claudication was found in 46 patients (61%), rest pain in 24 patients (32%) and gangrene in 5 patients (7%). As the atherosclerotic risk factors, cigarette smoking and hypertension were present in high rates, and ischemic heart disease was complicated in 31.4%. Endarterectomy with vein angioplasty was performed for 31 limbs and bypass operation usually using EPTFE grafts was for 66 limbs. Cumulative patency rate at five years was 72.6% in endarterectomy group, and 48.1% in bypass group. At ten years, 72.6% and 36.1%. Comparisons of the patency rate between two technics, endarterectomy was significantly better than bypass oparation in late postoperative period. Endarterectomy is recommended as the treatment of choice for femoropopliteal occulusive disease, because of the long-term patency.

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Coronary artery bypass grafting (CABG) was performed in 16 patients with impaired left ventricular function due to ischemic heart disease (IHD) and the surgical procedures and cardiac functions before and after operation were studied. Preoperative angiogram showed three vessel disease in all patients. The ejection fraction was less than 40% in all and the mean cardiac index (CI) was 1.97l/min/m². At operation arterial graft was used in 10 patients (Group-AG) and no arterial graft but saphenous vein graft was used in 6 patients (Group-SVG). The average total cardiopulmonary bypass time, aortic cross clamping time and the number of revascularized vessels in both groups showed no significant differences. However, intraaortic balloon pumping was necessitated in one of Group-SVG and the requirement of postoperative catecholamine was in higher ratio in Group-SVG than in Group-AG. Postoperative CI improved to 3.1±0.4l/min/m² and 3.3±0.3 l/min/m² in Group-AG and Group-SVG, respectively. The postoperative New York Heart Association Functional Class improved to Class I or II in all patients and there were no significant differences of the improvement between the groups. Conclusively, it seems that the arterial grafts can be used safely and extensively in CABG for impaired left ventricular function due to IHD.

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We studied the effects of the electrolyte composition (Na⁺, Ca²⁺) and amiloride, an inhibitor of Na⁺-Ca²⁺ exchange system on the postischemic reperfusion injury of rat hearts. The observed results are as follows: (1) Post-ischemic functional recovery increases with increased extracellular Na⁺ concentration of the initial reperfusate. (2) The recovery of cardiac performance is improved when the extracellular Ca²⁺ concentration of the initial reperfusate is reduced. (3) Amiloride, administered in the initial reperfustea, ameliorates cardiac damage in a dose-dependent manner (between 10^-6M and 10^-4M). It is concluded that the mechanism of post-ischemic reperfusion injury is dependent on the Na⁺-Ca²⁺ exchange system.

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Between Nov. 1981 and Dec. 1990, seventy-seven patients underwent surgical repair for abdominal aortic aneurysm (56, non-ruptured and 21, ruptured). There were no operative and hospital deaths in the non-ruptured group and 4 deaths (19%) in the ruptured group. To improve operative results by means of decreasing hemorrhagic blood loss and operative time, we have ameliolated some points of the technical procedures as follows. Dissection of the perianeurysmal tissue was limited to only the neck and anterior peritoneal surface of the aneurysm. Taping to keep the aorta and distal iliac artery was not applied and vascular clamps were placed without dissection of the posterior walls of the aorta and distal arteries. Proximal anastomosis of the Y-vascular prostheses were performed by the inclusion technique. The end-to-side method was used in distal anastomosis to the external iliac arteries routing behind the ureter. Even when aneurysmal dilatation involved the common iliac arteries, the orifices of the common iliac arteries were closed by continuous sutures bilaterally. In ruptured cases too, this standard technique was used without application of special means for proximal cross-clamping. Postoperative arteriography or enhanced computed tomography reveald thrombosis and reduction in size of residual aneurysm of the common iliac artery. By these improved surgical techniques, 25 cases (45%) of the 56 non-ruptured group had surgical correction of the abdominal aortic aneurysm without using homologous blood transfusion. Cumulative 5-year survival rate by Kaplan-Meier method of non-ruptured and ruptured group was 87% and 49% respectively.

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Histopathological changes in the vascular wall and the kidney following acute arterial occlusion were investigated in relation to the serum level of creatinine phosphokinase (CPK). A total of 23 adult mongrel dogs (10-15kg) were used. In order to produce acute arterial occlusion, the abdominal aorta (at the portion distal to the renal artery bifurcation) and four pairs of lumbar arteries were ligated. The ligation was released after 24hr of ischemia. The kidney was subjected to light and electron microscopic studies at 3hr after reperfusion. The femoral artery, which had undergone direct ischemic damage, and the carotid artery, which had not, were also examined. Hypertrophy of the glomerular basement membrane (GBM) was demonstrated in addition to the well-known renal tubular necrosis. Greater hypertrophy of the GBM was observed in association with higher CPK levels. When the CPK level exceeded 70, 000IU, hypertrophy of the GBM was observable even at the light microscopic level, and electron microscopy revealed the accumulation of fine granules within the GBM. Degeneration or disappearance of endothelial cells, often accompanied by degeneration of the media, was observed not only in the femoral artery but also in the carotid artery. These changes, especially at the electron microscopic level, were totally unrelated to the level of CPK. The above findings suggest that acute arterial occlusion induces vascular wall injury in the occluded as well as non-occluded arteries. This process appears to begin soon after reperfusion (180min), regardless of the degree of ischemic tissue damage as indicated in the level of CPK. Certain chemical mediators (e. g., neutrophils or oxygen radicals) may be involved in such a process.

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From January 1979 through May 1982, 36 premature infants less than 2.5kg and less than 35 weeks of gestation, including 24 patients with respiratory distress syndrome, underwent ligation of patent ductus arteriosus (PDA) due to being unresponsive to medical treatment. Ten patients died postoperatively mainly from intracranial hemorrhage and necrotizing enterocolitis. Surviving 26 patients were examined for developmental sequelae based on questionnaire survey. One infant died of respiratory failure secondary to severe bronchopulmonary dysplasia 28th month after operation. We found no evidence of recurrent ductal patency following ligation during the follow-up period. Twenty four patients exhibited normal motor and mental development to attend the ordinary elementary school everyday, but one patient shows mental retardation. Most of patients suffered from the frequent upper respiratory infection in childhood to require rehospitalization. There are no patients with hoarseness, but 2 patients developed funnel chest and one required the operation. One third of the patients had ophthalmological handicap (myopia or strabismus). Surgical ligation of PDA in premature infants seems to reduce the duration of postoperative mechanical ventilation and the incidence of bronchopulmonary dysplasia. Analyzing long-term follow-up indicates that infants who undergo PDA ligation grow almost normally and do not appear to be at increased risk for sensorineural handicaps. Therefore we emphasize that surgical ligation of PDA is an effective and appropriate treatment of choice for significant PDA in premature infants.

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This study was designed to evaluate the myocardial protection with observation of the monophasic action potential (MAP) which was recorded by suction electrode. Using the isolated working rabbit hearts, amplitude, duration of MAP at 50% repolarization level (MAPD₅₀), aortic flow and heart rate were measured after reperfusion. The comparative study obtained for all five groups under the following various conditions of the aortic cross clamping are stated as follows. Myocardial temperature were maintained at 20°C during aortic cross clamping. Group I was treated with St. Thomas' Hospital cardioplegic solution. The cardioplegic solution was infused every 20min during ischemia and kept at 20°C. The hearts of group I was divided into four sub-groups, all of which were infused with different concentration of diltiazem (D) in cardioplegia: group Ia D=0μg/ml (n=10), group Ib D=1μg/ml (n=5), group Ic D=5μg/ml (n=5). group Id D=10μg/ml (n=5), and in group II cardioplegic solution was not used. The amplitude of MAP following 30min working mode of reperfusion in group I showed a significantly higher recovery compared to those in group II. The MAPD₅₀ of MAP following 30min working mode of reperfusion in group I showed a significantly lower recovery compared to those in group II, and 10min Langendorff mode in group I a showed a significantly higher recovery compared to those in group Ib, group Ic and group Id. 20min working mode in group Ia and group Ib showed a significantly higher recovery compared to those in group Ic and group Id. The heart rate following 30min working mode of reperfusion in group Ia and group Ib showed a significantly higher recovery compared to those in group Ic and group Id. The aortic flow following 30min working mode of reperfusion in group Ia and group Ib showed a significantly higher recovery compared to those in group Ic, group Id and group II. We would like to conclude that the permeability of large amount of calcium across myocardial cell membrane seems to be depressed by diltiazem added to cardioplegia. But when the concentrations of diltiazem in cardioplegia was over 5μg/ml, it showed negative inotropic action and negative chronotropic action.

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Out of 104 patients with perimembranous or infundibular-isolated ventricular septal defect (VSD), causative factors of Prol and AR, and the operative indication were studied in 17 with prolapse of the aortic cusp (Prol) and 10 with aortic valve regurgitation (AR). The left to right shunt ratio and the size of VSD were smaller in patients with Prol or AR than in those with the normal aortic cusp, suggesting that hemodynamics might take part in the cause of Prol or AR. Twenty-two patients underwent VSD closure only, four valvuloplasty and one aortic valve replacement. Residual AR was occurred in three out of ten patients. After surgery, AR was disappeared in six out of seven patients with the first grade preoperative AR, but AR remained in all two patients with the second grade preoperative AR. Careful preoperative observation and early operation before the appearance of AR are the important factors for avoiding residual regurgitation after aortic valvuloplasty.

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The degree of intermittent claudication is difficult to evaluate objectively; therefore, the therapeutic efficiency of a drug is difficult to test in patients suffering from intermittent claudication. The purpose of this paper is to know whether treadmill test is useful to evaluate objectively the degree of intermittent claudication. 20 patients suffering from a peripheral arterial occlusive disease with intermittent claudication (Stage II) were investigated. PGE₁ incorporated in lipid microspheres (Lipo PGE₁) was infused (10μg/day) with one shot on 7 consecutive days into the forearm vein of patients. Painfree walking distance and maximum walking distance were measured on treadmill (3.0km/h, 5% incline). Brachial systolic pressure and ankle pressures were measured before and after exercise, and ankle/arm pressure ratio and ankle pressure difference between the pre-exercise and post-exercise values were calculated. All measurements were performed before and 7 days after beginning of treatment. Painfree walking distance was prolonged from 72.5±41.4m before treatment to 92.0±53.7m after treatment, with significant difference (p<0.01). However, no significant changes of ankle/arm pressure ratio, ankle pressure difference and maximum walking distance were observed. It is concluded that measurement of painfree walking distance on treadmill was useful to evaluate objectively the degree of intermittent claudication.

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The current technique of retrograde coronary sinus perfusion (RCSP) has been provided double cannulation of the vanae cavae and isolation of these vessels, and right atriotomy. Most aortic valve and coronary artery bypass surgery are performed with single venous cannulation. We used a new RCSP catheter, Retroplegia (Research Medical Co.), and performed Cabrol procedure safely with single venous cannulation. This catheter can be cannulated to the coronary sinus through a right atrial purse-string suture without opening the right atrium. The occlusion balloon is inflated spontaneously by infusing the cardioplegic solution and occlude the coronary sinus adequately and nicely. This catheter has double lumen, one is for infusion of the cardioplegic solution, the other is for measurement of the coronary sinus pressure. We believe that this catheter is useful for RCSP of the cardiac surgery using single venous cannulation.

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Rupture of the posterior wall of the left ventricle is rare but it is one of the fatal complications which can follow mitral valve replacement (MVR). Of 216 MVR patients, including 51 who had double valve replacements, we have had four patients (1.9%) with this complication. The rupture occurred on the table in one patient and about 40 to 90min after entering ICU in the others. All the ruptures were repaired under cardiopulmonary bypass and cardioplegic arrest. The site of rupture was type I in two cases and type II in the other two. Two patients expired. One patient who had been repaired in the operating room died from multiple organ failure after a stormy course of two week's duration, and one who had been repaired in ICU died from uncontrollable hemorrhage. In the remaining two patients, one with a type I and one with a type II rupture, successful treatment in ICU was achieved by suturing an equine pericardial patch to the normal endocardium and mitral ring over the entire area of laceration through endocardial site after removal of the valve prosthesis in the first place, and then wrapping the area of epicardial laceration with another equine patch. In order to reduce mortality in patients with left ventricular rupture, repair from inside of the heart using an equine patch described above was very effective, and the preparation to perform the operation immediately after the onset of rupture in ICU is an important consideration as well.

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A 52 year old male who have stabbed in his anterior chest by a knife developed hemopericardium 30 years ago was admitted to our hospital because of general fatique, facial edema and swelling of liver L. Chest X-ray revealed calcification of pericardium and cardiac catheterization showed dip & plateau in right ventricle. Pericardium was about 2 to 10mm in thickness and pericardiectomy was successfully performed. It is difficult to determine that this case caused by trauma or tuberculosis. But from macro-and microscopic findings, this case might be constrictive pericarditis developed from traumatic exudative pericarditis due to penetrating stab wound of the heart.

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A 66-year-old female who complained severe abdominal pain with hemorrhagic shock underwent emergency laparotomy. Further inspection revealed a ruptured aneurysm (φ3cm) of the main trunk of the right renal artery. To avoid the prolonged hemorrhagic shock status, a right nephrectomy was performed. The pathological examination revealed the fusiform atherosclerotic aneurysm of the renal artery located at 1cm proxymal from the hilm of the right kidney. Convalescence was uneventful. In previous reports, most cases with ruptured aneurysm of the renal artery underwent the nephrectomy. Although it is important to serve the renal function, we also performed the nephrectomy to limit the duration of shock status. The procedures such as aneurysmectomy with revascularization may apply on further cases, if possible.

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A 69 year old man who was admitted with hoarseness and diagnosed as aneurysm of the diverticulum of the ductus arteriosus was reported. Operation was performed through a median sternotomy under partial cardiopulmonary bypass. Saccular form aneurysm, had a stalk attaching to left pulmonary artery, was repaired using Dacron patch prosthesis. His postoperative course was uneventful except transient left pleural effusion. Because of fragirity of aneurysm in the adult, early surgical intervention is recommended. To our knowledge, this is 11th surgically treated case to be reported in the literature in Japan.

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Coronary artery bypass surgery in a 54-year-old female with severe calcified ascending aorta was performed with aortic no touch technique, Extracorporeal circulation with femoral cannulation was performed, and bilateral internal thoracic acteries and gastroepiploic artery were used as grafts under ventricular fibrillation and hypothermia without aortic cross-clamping. No neurological complication was observed and postoperative course was uneventful. We think the aortic no touch technique is safe and reliable in the coronary revascularization with severe calcified aorta.

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We describe two cases of aortic regurgitation with dove-coo murmur that required aortic valve replacements. In the first case, there were three small perforations of the cusps, two in the noncoronary cusp and one in the right coronary cusp. The cause of the cusp perforations was unclear. In the second case, there were two perforations of the cusps, one in the left coronary cusp and another small one in the right coronary cusp, along with a subannular pseudoaneurysm. The cause of the cusp perforations was an infective endocarditis. Before 1955, aortic regurgitations with dove-coo murmur were mostly reported to be originated by retroversion of the valve cusps due to syphilis. After 1960, syphilis was replaced by various diseases that bring about perforations, tears and retroversions of the cusps. The condition which is concerned in the development of the dove-coo murmur is that the aortic valve cusps have lesions without calcification and preserve the flexibility.

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A 60 year-old female underwent mitral valve replacement with a Duromedics valve. She was in good condition during weaning from cardiopulumonary bypass. However, rupture of the left ventricle was manifested by massive bleeding just after dis-contination of cardiopulmonary bypass. A large hematoma accompanied by bleeding was observed in the posterior atrio-ventricular groove. The patient was quickly put back on total cardiopulmonary bypass. A slight laceration was suspected in the membranous portion of the ventricular septum just below the mitral annulus. Re-valve replacement was performed by reinforcing the mitral annulus with a Dacron patch. This patient was removed from cardiopulmonary bypass, but died of multiple organ failure in 7 days after operation. At autopsy, the left ventricular rapture was identified just below annuls in the area of the atrioventricular groove. Furthermore, extensive hematoma was noted in the posterior atrioventricular groove.

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A 3-month-old girl of univentricular heart of left ventricular type with atresia of left atrioventricular valve (LAVV) and coarctation of the aorta (Co/AO) is presented. UCG and angiography revealed concordant AV connection with straddling RAVV with transposed great arteries [SDDT]. The following pressures (in mmHg) were noted on catheterization: RA mean 1 (a=3, v=1), LA mean 12 (a=17, v=14), LV 84/0/8, Ao 81/41, and PA 74/39. Patent foramen ovale (PFO) was restrictive and balloon atrioseptostomy was not feasible. Blalock-Hanlon atrial septectomy (8×6mm), subclavian flap aortoplasy (SFA) and pulmonary arterial banding were performed simultaneously under bilateral thoracotomy. Acute renal failure occurred after surgery and the girl required peritoneal dialysis for 5 days. At 6 months after surgery, girl is doing well. There will be a predictable fall in pulmonary vascular resistance after atrial septectomy and SFA with a ligation of PDA may result transient increase in systemic resistance. Therefore, atrial septectomy and SFA in conjunction with pulmonary arterial banding should be done simultaneously.

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Two cases of abdominal lymphatic disruption following surgery on the abdominal aorta are presented, one causing para-aortic lymphocyst and the other resulting in chylous ascites. The 1st patient ultimatery received operative drainage into the lymphocyst. The 2nd patient responded to twice paracentesis and total parenteral nutrition for one month. We need to be aware of these complications and pay attention to prevention and early diagnosis.

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In a consecutive series of 160 surgically treated abdominal aortic aneurysm, four patients with acute aortic thrombotic occlusion of an abdominal aortic or iliac aneurysm were encountered. Three of four aneurysms were 7cm in diameter or smaller. Also, 3 of 4 patients had chronic occlusive disease of legs. Our mortality rate was 75%. The recommendation is made that all abdominal aortic aneurysms be resected if there is substantial associated distal occlusive disease.

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