Three patients, who received infrarenal aorto-iliac bifurcation grafts, complained of flaccid and insensible feeling on lower extremities immediatedly after surgery. These symptoms were supposed due, in two cases, to spinal cord ischemia or, in remaining one case, to ischemic change of the peripheral nerve, In former cases, spinal cord hypoxia might be caused by interrupted blood supply through spinal artery as it was intercepted temporarily but for about three and a half hours during surgical procedures. In the latter case, cramping of the left iliac artery lasted for five and a half hours, which might result in anoxic damage of the peripheral nerve. Hyperbaric oxygenation (HBO) at two atmospheric absolute (ATA) pressure for 75min and 3 ATA for 90min were repeated everyday for them. In all cases, almost complete sensorimotor recovery was obtained after 15 to 30 instances of HBO, which was combined with physical therapy. HBO seemed to have improved early hypoxic and edematous damages of the spinal cord or peripheral nerve. As an unfavorable complication of abdominal aortic surgery, incidence of sensorimotor disturbance of the extremities is infrequent and/or unpredictable, however, once it occurs, no effective therapeutic maneuvers were developed yet. Through these clinical data, HBO should be introduced more actively for such disorders. One of the key issues to enhance the effect of HBO is that, HBO should be introduced as soon as possible once postoperative nuerologic disorders were diagnosed.

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Cerebral protection during surgical procedure of aortic arch aneurysm is one of the most important factor which limits the time of surgical repair of the aortic arch and arch branches. We introduced the selective cerebral perfusion system by gravity with cold blood for repair of aortic arch aneurysm from 1988. This study was undertaken to determine whether this new selective cold blood cerebral perfusion system is usefull for repair of aortic arch aneurysm. From July 1988 to May 1991, twenty-three patients with aortic arch aneurysms were repaired using the selective cerebral perfusion system with cold blood. Both carotid arteries were selectively perfused with oxygenated cold blood (16°C) via the reservoir combined with heat-exchanger fixed 1.5 meter high from the head of the patient. Surgical repair was performed under moderate core hypothermia (20-25°C) avoiding prolonged cardiopulmonary bypass to rewarm the patient. Cerebral perfusion pressure was 45 mmHg (mean) and perfusion flow via the carotid arteries was 400ml/min. Mean selective cerebral perfusion time was 60min and mean cardiopulmonary bypass time was 193min. Emergency operations were performed in seven of 23 patients because of ruptured aortic arch aneurysms. There was no intraoperative death. Three of 23 patients (13%) died due to postoperative complication. Nineteen of 20 survivors discharged from the hospital and are good clinical condition. One patient needs the care for rehabilitation in the hospital due to cerebral infarction. Although our experience is limited, successful cerebral protection and avoidance of prolonged cardiopulmonary bypass were achieved. Selective low pressure cerebral perfusion with cold blood may be a useful method for repair of aortic arch aneurysm.

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There were 16 patients who developed acute renal failure (ARF) follwing cardiovascular operation using extracorporeal circulation. They were treated by either CPD or CAVH because their ARF were resistant to medical treatment. These patients were divided into three groups according to their treatment; 7 patients treated by CPD (Group A), 5 patients treated both CPD and CAVH (Group B), 4 patients treated by CAVH (Group C). The survival rate was 33% in Group A, 20% in Group B, and 0% in Group C. The prognosis of the each group was poor. CPD and CAVH were effective to control the concentration of serum potasium and water removing. But CPD and CAVH were not very effective to control the concentrations of serum creatinine and blood urea nitrogen. There were three patients who developed low proteinemia which was one of the side effects of CPD. Seven of nine patients treated by CAVH, developed bleeding. The side effects of CAVH were seemed to be more severe than those of CPD.

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Ten patients after coronary artery bypass grafting had reoperatinons and eight patients underwent postoperative PTCA at Nihon University Hospital from 1970 to July 1991. The difference of age between the reoperation group and the postoperative PTCA group is not significant. Most patients of the reoperation group and all of the PTCA group were male. Symptoms of the patients who required again surgical treatment or PTCA were almost reattack of angina and many cases were complicated by the coronary risk factors, particularly uncontrolled hypercholesterolemia and smoking. The bypass numbers of the reoperation group in the first operation were 2.1 and those of the PTCA group were 3.5. The difference of them was statistically significant (p<0.05). The period from the primary operation to the second treatment also showed statistically significant difference between two groups (p<0.05) (reoperation group: 81.8 months, PTCA group: 55.7 months). In the reoperation group, there were two operative deaths, two late deaths (not caused by heart disease), and the others remained asymptomatic. In PTCA group, no one had died, but four patients repeated attacks of chest pain after PTCA (mean interval 2.3 months), and two of them underwent re-PTCA. For a symptomatic case whose native coronary arteries or vein grafts show progressive stenosis and who have undergone PTCA, reoperation is recommendable as an effective treatment to relieve the symptom.

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The GRF glue consists of mixture of gelatine and resorcine. The mixture is hardened by the addition of medical formaldehyde. Resorcine is diphenole which reacts with formaldehyde, creating tridimentional network. We performed microvascular anastomosis of abdominal aorta of the rat using GRF glue and the histologial study by the light microscope and the scanning electron microscope. Re-endoterization began from two days after anastomosis and completed at ten days to two weeks after anastomosis. From scanning electron microscopic study the invasion of macrophages and platelets in the case of anastomosis using GRF glue was less than in the case of manual or laser anastomosis. We revealed that GRF glue is very useful for bonding of micro vessels.

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To investigate the efficacy of human superoxide dismutase (h-SOD) in myocardial ischemia and reperfusion with difference of administration of h-SOD, twenty four dogs were subjected to 120min ischemia by the cross clamping of the ascending aorta, and followed by 60min reperfusion, The dogs were randomly assigned to three groups: group G, h-SOD (8mg/kg) was injected into the cardiopulmonary bypass (CPB) circuit 5min prior to reperfusion; group L, h-SOD (3mg/kg) was administered by bolus injection through the aortic root into the coronary artery 1min prior to reperfusion; group C, nothing was administered. The values of creatinine phosphate MB isozyme (CPK-MB) and a-hydroxydehydrogenase (HBD) in coronary effluent, and lipid peroxides (LPO) in coronary artery and sinus blood, were measured during CPB. Cardiac function was evaluated by cardiac index (C. I.) and LV max d_p/d_t, and it was expressed as a percent recovery of pre-CPB state. Myocardial water contents as myocardial edema were measured after CPB. Effluents of CPK-MB and HBD at 60min after reperfusion were less in group L than group G, C. Generations of LPO (A-Cs difference) were less at 5min after reperfusion in group G, L than group C and there were significant differences between group G, L and group C. The percent recovery of C. I. and LV max d_p/d_t at 60min after reperfusion was superior in group G, L than group C and there were significant difference between group G, L and group C. Myocardial water contents at 60min after reperfusion were less in group G, L than group C and there were significant difference between group G, L and group C. In the lipid peroxides generation, cardiac function and myocardial edema except effluents of cardiac enzymes, group G was as well as group L. These data suggest that the injection of h-SOD into the CPB circuit just before reperfusion is effective to prevent the reperfusion injury as well as the administration through the aortic root.

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Two cases of blue toe syndrome were effectively treated by PGE1. Case 1 was an 80-year-old man who had an ulcer lesion of the 5th toe. Angiography indicated the symptoms were caused by microemboli from an extended lesion of the aorta and iliac artery. The wound was healed by lipo PGE1 (10μg×30 days). Case 2 was a 54-year-old man who had dull pain and skin color change of the 3rd and 4th fingers. A thrombus could not be detected by transthoracic echocardiography, but was found by transesophageal echocardiography. The symptoms improved by PGE1 (60μg×20days). Blue toe syndrome is induced by a microembolism in the peripheral arteries, and thus the conventional treatment has been the administration of fibrinolysins and anticoagulants. PGE1 was used in this study for the first time in consideration of its vasodilating effect on the collateral circulation and to prevent a secondary thrombus by inhibiting platelet aggregation.

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Ebstein's anomaly is a rare congenital heart disease. We treated two patients with this malformation using a new surgical technique proposed by Carpentier. The technique consists of reconstructing the longitudinal plication of the atrialized chamber and repositioning the anterior and posterior leaflets of the tricuspid valve to the true anatomical annulus. The first patient, a 16-year-old boy, underwent surgery on September 5, 1990, and the second patient, a 13-year-old girl, on July 24, 1991. Atrial septal defect was seen only in the second patient, and was closed without a patch. Aortic cross clamping lasted an average of 96 minutes. The surgical technique was relatively easy, and the postoperative course was uneventful in both patients. The cardiothoracic ratio was reduced from 68% to 54% in the first patient and from 64% to 52% in the second. We concluded that Carpentier's operation led to good clinical results for Ebstein's anomaly.

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Two patients with an aorto-iliac arteriovenous fistula as a complication of abdominal aortic aneurysms were presented. Both patients showed pulsating abdominal mass, and swelling of unilateral leg. The fistula was preoperatively diagnosed in one and in another it was suspected intraoperatively by careful palpation of continuous thrill on the aneurysm. Successful surgical management was accomplished in both patients. Awareness of this clinical entities is necessary to manage this rare complication in abdominal aortic aneurysm surgery.

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We have recently experienced a case of impending ruptured aneurysm of the common iliac artery associated with a gelatinous substance in the retroperitoneal space. A 69 year-old male had been diagnosed as a left common iliac aneurysm at another hospital by CTscan during the examination of lower abdominal pain. At the midnight of the day he admitted, the severity of pain gradually intensified. But there was no sign of anemia nor hypotension. Next morning CTscan showed low density left retroperitoneal mass. The patient underwent emergency laparotomy. The further inspection revealed about 600cm³ of gelatinous substance in left retroperitoneal space without the sign of aneurysmal rupture. A bifurcated graft replacement was performed. The low density mass was not recognized by CTscan done 42 days postoperatively. Electrolyte study of the gelatinous substance indicated its serous leakage through the impending ruptured aneurysm. Our present report constitutes a completely distinct variety of common iliac aneurysm, associated with a gelatinous substance in retroperitoneal space without a major rent of the aneurysmal wall.

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Diffuse hepatic arteriovenous malformation is extremery rare disease. A 69-year-old female was admitted to Nagoya Ekisaikai Hospital because of heart failure in NYHA class III. A selective celiac angiogram, echo cardiography and cardiac catheterization revealed high output cardiac failure secondary to diffuse hepatic areteriovenous malformations. Hepatic artery embolization with steel coils was performed. This resulted in amelioration of heart failure.

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Mediastinal wound infection following sternotomy is a serious post-operative complication. Therefore a median sternotomy must be avoided for the patient having a low cervical terminal tracheostomy. A 64-year-old man, who had undergone a low cervical terminal tracheostomy after total laryngectomy, complained of an anterior chest oppression. His coronary angiography revealed 75% stenosis of the left main coronary ostium. He underwent coronary artery bypass grafting through left thoracotomy. Extracorporeal circulation with femoral cannulation was performed, and the left internal thoracic artery and right saphenous vein were used as grafts under hypothermic fibrillatory arrest without aortic cross-clamping. The left thoracotomy approach is a safe and advantegeous method in selected patients.

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A case of subclavian vein stenosis is reported that was treated with external jugular-cephalic vein bypass, which was performed under local anesthesia and took short time for operation because of single anastomosis. This procedure resulted in salvage of the access and rapid resolution of the associated upper extremity swelling.

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We report a case of a solitary iliac aneurysm-fistula of the sigmoid colon. A 68-year-old male was diagnosed as having diverticulum of the sigmoid colon by barium enema at a near-by hospital with a major complaint of melena. He continued to have massive melena although he received sigmoid colectomy. His condition eventually deteriorated into shock and he was transferred to our department. Angiographic findings showed a left common iliac aneurysm. Under the diagnosis of a rupture of a sigmoid colon, emergency operation was performed including aneurysmectomy and bypass formation between the femoral and femoral artery as an extraanatomical bypass. The patient developed multipul organ failure following the sepsis and died 8 days postoperatively. An aneurysm-intestinal fistula is a complication of an aneurysm. The problem of this disease is the difficulty in making a definite diagnosis with high mortality rate. We should consider the possibility of an aneurysm-intestinal fistula for the patient with gastrointestinal bleeding of the unknown origin.

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Patient is a 58-year-old man who had a thoracoabdominal aortic aneurysm with abdominal angina due to the occlusion of celiac artery with mural thrombus in the aneurysm. He had a recurring abdominal pain for half a year, and relapsing elevation of serum transaminase levels. Graft displacement was performed, followed by reattachment of visceral vessels, celiac artery and superior mesenteric artery, using partial extracorporeal circulation. Abdominal angina due to thoracoabdominal aortic aneurysm has been seldom reported. It has been said that complete revascularization is not required as surgical therapy, and single vessel revascularization is sufficient to reduce symptoms. Preoperative angiography will reveal which vessels supply dominant blood flow to visceral organs, therefore, angiographic examination should be performed essentially prior to surgery.

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