We experienced 6 cases of intractable perioperative myocardial ischemia with coronary spasm that was successfully treated with fasudil, a Rho-kinase inhibitor. Three of the patients (aged 49-81 years) showed ST elevation on electrocardiograms and abrupt circulatory collapse after off-pump coronary artery bypass grafting. Emergeny coronary angiogram revealed severe spasm of their own coronary arteries and/or bypass grafts. Since intracoronary and/or intragraft injection of isosorbide dinitrate (ISDN) was ineffective, we administered fasudil into the spastic vessels, and that completely resolved the spasm. The other 3 patients (aged 55-77 years) suffered myocardial ischemia during the operation, though intravenous vasodilators including ISDN, diltiazem and nicorandil had been administered continuously. Their ischemia occurred when the aorta was declamped, the pericardium opened, or the bypass graft was anastomosed, respectively. We decided to use fasudil in these cases since ISDN was ineffective, or severe spasm was found on intraoperative inspection. Administration of fasudil successfully relieved the ischemia, and subsequently all 3 patients could be weaned from the cardiopulmonary bypass during the operation. Fasudil completely resolved the myocardial ischemia in all 6 patients. In conclusion, fasudil, a Rho-kinase inhibitor, is a useful agent for perioperative myocardial ischemia including coronary spasm that is resistant to intensive conventional vasodilator therapy. We should administer fasudil and relieve spasms as early as possible to rescue patients with intractable ischemia.

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We evaluated the efficacy of sternal coaptation pins used to improve the fixation of the transected sternum after coronary artery bypass grafting (CABG) with the internal thoracic artery (ITA). The subjects were 37 patients who underwent scheduled single CABG with ITA in our department and they were classified into two groups, i. e., Group A, without sternal pins (18 patients), and Group B, with sternal pins (19 patients). The efficacy was assessed by the following measurements : drain bleeding volume up to 12 and 24 h after ICU admission, the time until the removal of drain, surgical site infection (SSI) and the maximum split level between the sternal body and manubrium after surgery. Drain bleeding volume up to 12 and 24 h after ICU tended to be less in Group B. The time until the removal of drain was significantly shorter in Group B. SSI was 17% in Group A but 0% in Group B. The use of sternal coaptation pins reduced misalignment of the coapted sternum, and we belive that the use of sternal coaptation pins contributed to the early removal of drain, and SSI reduction.

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Adequate exposure is crucial for successful mitral valve surgery. We report simple techniques for optimizing mitral valve exposure via conventional left atriotomy. The right side of the pericardium is sutured to the chest wall after medial sternotomy and pericardiotomy. We mobilize both the superior and inferior vena cava by dissecting the pericardium on their right side. Tourniquets are placed around both venae cavae and hitched up to the left after bicaval cannulation. Then the right side of the left atrium is lifted up and exposed. A longitudinal incision of the left atrium allows excellent exposure of the mitral valve using a single retractor. We adopted these procedures for 38 consecutive patients for mitral valve plasty, and additional incisions were not required. Simple mitral plasty procedure in 18 cases required 212±32 min for operation, 120±22 min for extracorporeal circulation and 88±18 min for aortic cross clamp. We conclude that this method is simple and does not lengthen the procedure.

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Left ventricular non-compaction (LVNC) is a congenital abnormality caused by arrest of the normal process of myocardial compaction, and the prognosis of LVNC is poor with progressing heart failure. Reports of cardiac operations in patients with LVNC are rare. We resected a right atrial myxoma in a 69-year-woman, who had suffered from severe heart failure and in whom echocardiogram indicated LVNC. Using myocardial protection for the immature myocardium, the postoperative course was uneventful and the patient was discharged 19 days after the operation. We must pay attention to cardiac function after discharge because of the poor prognosis.

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Constrictive pericarditis is usually a chronic inflammatory process. We encountered a case of acute constrictive pericarditis caused by infectious pericarditis in a patient receiving pericardial drainage for pericardial effusion. We performed emergency pericardiectomy and primary closure in the active phase of infection. An 82-year-old man was referred to our hospital for investigation and management of pericardial effusion. The patient was admitted, and continuous pericardial drainage was performed. After 2 days of drainage, he had fever, and after 7 days, there was purulent exudate in the drain tube. Methicillin-sensitive Staphylococcus aureus was identified by culture of the purulent exudate. Despite administration of antibiotics, he developed malaise, anorexia, and generalized edema, and he also began to suffer from dyspnea. Computed tomography demonstrated infected pericardial effusion, while a right ventricular pressure study showed a “dip and plateau” pattern. Pericardial drainage and irrigation were done via a small subxyphoid skin insicion. However, his hemodynamics did not improve and oliguria was noted. Because more extensive drainage was necessary, we performed emergency on-pump beating pericardiectomy via median sternotomy. Along with administration of antibiotics, continuous mediastinal irrigation with saline was done via mediastinal, pericardial, and chest drain tubes for 7 days after the operation. His postoperative course was relatively uneventful, and he was discharged after recovery.

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A 53-year-old woman complained of symptoms of congestive heart failure and was admitted to a local hospital. Transthoracic echocardiography showed pericardial effusion and left ventricular aneurysm. The patient was transferred to our hospital for examination for treatment. Coronary angiography demonstrated triple vessels disease. The patient underwent left ventricular reconstruction and coronary bypass grafting. The operative findings showed no adhesion between the aneurysm and the pericardium. The pathological examination after operation indicated a ventricular pseudo-false aneurysm. The differentiation of left ventricular pseudo-false aneurysm from pseudo-aneurysm can be difficult.

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A 39-year-old woman underwent aortic valve replacement (AVR) with a 21 mm St Jude Medical prosthesis and mitral valve replacement (MVR) with a 27/29 mm On-X valve prosthesis when she was 38-year-old, and she was discharged uneventfully. Five months after the operation, she was admitted with aggravated dyspnea. Upon admission she went into serious heart failure, followed by cardiogenic shock. Cineradiography showed a restricted opening of the On-X mitral valve prosthesis and transesophageal echocardiography demonstrated thrombus formation on the mitral valve annulus. We diagnosed thrombosed valve and reoperated urgently. Intraoperatively we found a large amount of fresh thrombus extending from the sewing cuff that restricted valve motion. The valve was cleaned and left in place. Although the heart recovered well, she lost some neurologic functions and was transferred to another hospital for rehabilitation. We also investigated the opening angle of the On-X mitral prosthesis in other patients who had clinically normal valve function.

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Myotonic dystrophy (MyD) is a rare progressive multisystemic-inherited neuromuscular disease. It is often associated with cardiovascular disorders which require surgical procedures. However, it high sensitivity to anesthetic and neuromuscular blocking agents may result in respiratory complications. Myotonic dysorder due to hypothermia and conductive disorder following open-heart surgery are also risk-factor of perioperative management, thus open-heart surgery for MyD has rarely been reported. We describe the perioperative management for a MyD patient with an atrial septal defect (ASD) and mitral regurgitation (MR), who successfully underwent cardiac surgery. Minimally invasive cardiac surgery (MICS) with reverse-L-shaped partial sternotomy were useful method to minimize postoperative respiratory problems.

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An 83-year-old woman with unstable angina pectoris underwent percutaneous coronary intervention (PCI) of the left circumflex artery, and her condition improved. However, on the eighth day after PCI, she went into a stated shock, and echocardiogram confirmed a large amount of pericardial effusion. Pericardiocentesis was immediately performed, and bloody pericardial effusion was drained. Cardiac rupture was suspected, although the cause was unknown. Emergency sternotomy was performed, and blow out type cardiac rupture in the center of a thumb-sized infarction was found at the area of the obtuse marginal branch. The ruptured left ventricular wall was successfully closed with 2 mattress sutures because the infarcted area was relatively small. Postoperative course was good, and she was discharged on the 25th postoperative day. In this case, the cause of cardiac rupture was thought to be a small branch of the left circumflex artery, which was occluded during PCI. This is one of the rare but important mechanisms of cardiac tamponade after PCI.

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A 71-year-old woman was admitted with general fatigue and appetite loss. Computed tomography showed hypertrophy of the pericardium surrounding the anterior of the right ventricule (RV). Cardiac catheterization demonstrated a rise of RV end-diastolic pressure and a dip-and-plateau pattern of the pressure curve of RV without any coronary disease. Therefore, we diagnosed heart failure due to constrictive pericarditis and performed pericardectomy using an Ultrasonic Scalpel through a median sternotomy without cardiopulmonary bypass. No improvement of the hemodynamics during the operation was found despite subtotal pericardectomy. Then, we performed the waffle shape cutting of the residual epicardium using an Ultrasonic Scalpel and obtained improvement of the hemodynamics on the operation. We then obtained increased cardiac output and the improved hemodynamics without a dip-and-plateau of the pressure curve of RV. No recurrence of the constrictive pericarditis has been found for two years. Hence, we consider that the waffle shape cutting of the epicardium using an Ultrasonic Scalpel is one of the most useful surgical repairs.

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A rare surgical case of chronic expanding hematoma in the pericardial cavity is reported. A 78-year-old man had undergone coronary artery bypass grafting 2 years previously. He had suffered from general malaise, increasing shortness of breath and systemic edema from 18 months after the operation. Echocardiography revealed an intrapericardial mass compressing the cardiac chambers resulting in insufficiency of the ventricular expansion. Under extracardiopulmonary bypass and cardiac beating, resection of the mass and additional coronary artery surgery were implemented. The mass was encapsulated with thick fibrous membrane containing old degenerated coagula the bacterial culture of which was negative and was histopathologically diagnosed as chronic expanding hematoma. The patient's postoperative course was uneventful and symptoms with cardiac failure were relieved. There has been no recurrence for more than 18 months.

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Ruptured acute type A aortic dissection in a patient with persistent left superior vena cava (PLSVC) and absence of a bridging innominate vein is rare. A 71-year-old woman presented with a pain in the right side of the neck and nausea. Ruptured acute type A aortic dissection was diagnosed. CT scan revealed a persistent left superior vena cava and absence of a bridging innominate vein. Emergency hemi-arch replacement was performed. After CPB was established with right femoral artery return and right SVC (RSVC), IVC venous drainage was placed. An L-shaped venous cannula was directly placed into the LSVC. After core cooling, the ascending aorta was clamped and the right atrium was incised for retrograde cardioplegia. At a rectal temperature of 28°C, circulatory arrest was started and retrograde cerebral perfusion was performed through right and left SVC. Her postoperative course was uneventful. In cases of ruptured acute type A aortic dissection in a patient with persistent left superior vena cava (PLSVC) and absence of a bridging innominate vein, standard hemiarch replacement can be performed with direct venous cannulation of LSVC for reliable retrograde cardioplagia and retrograde cerebral perfusion.

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We describe the case of a 59-year-old man who developed constrictive epicarditis 2 months after an episode of acute pericarditis. Magnetic resonance imaging demonstrated parietal pericarditis and epicarditis. Through a median sternotomy, a markedly thickened parietal epicardium was noted which was removed where possible. After this procedure, however, no improvement of the hemodynamic parameters was observed. We attempted removal of the epicardium, but the procedure had to be abandoned due to myocardial injuries and bleeding. Multiple longitudinal and transverse incisions were carefully performed on the thickened epicardium, following which relief of constriction along with a remarkable improvement of the hemodynamic status was achived. Although the dip and plateau pattern was persisted, cardiac index increased from 2.2 to 2.9 l/min/m² and the pulmonary capillary wedge pressure decreased from 20 to 13 mmHg. Patient's postoperative course was uneventful and he was discharged on postoperative day 22.

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A 34-year-old woman was admitted with a history of syncope and a mass was detected in the right atrium (RA) by transthoracic echocardiography (TTE). Preoperative chest computed tomography (CT) also demonstrated an RA tumor measuring 4×3 cm. We performed resection of the RA tumor under cardiopulmonary bypass. Histopathological findings showed that the tumor was an angiomyolipoma. It is well known that angiomyolipomas are most frequently found in the kidney and are associated with tuberous scleroses. There was no evidence of tuberous sclerosis in this case. Primary tumors of the heart are rare. However, there have been a few intracardiac angiomyolipomas reported previously.

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A 76-year-old woman with abdominal aortic aneurysm coexisting horseshoe kidney and pelvic arteriovenous malformation (AVM) is reported. Operation was performed by a transperitoneal approach via typical median laparotomy. The aneurysm was successfully replaced by a bifurcated prosthetic graft without division of the renal isthmus. Cold lactated Ringer solution was injected into an aberrant renal artery at the time of aortic cross-clamping. This was useful not only to protect the kidney against ischemic injury, but also to know the perfusion area of the vessel. The aberrant renal artery was attached to the prosthetic graft following the aortic proximal anastomosis. Though a part of the asymptomatic AVM, which involved the left ureter, ovary, and uterus, was located anterior to the left iliac arteries, distal anastomoses at the internal and external iliac arteries were done smoothly. No surgical intervention was applied to the AVM in the operation. The post-operative course was uneventful.

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Case 1 was a 48-year-old mother who was under observation for Marfan syndrome and thoracic aortic dilation. She was brought to the hospital with chest pain, and a CT scan revealed acute aortic dissection (Stanford A). Aortic incompetence was also observed, and an emergency Bentall procedure was performed. Case 2, her daughter, was a 26 years old and 39 weeks pregnant. She did not meet the diagnostic criteria for Marfan syndrome. She experienced severe back pain on the same day that her mother was admitted for aortic dissection. Because the patient did not agree to the use of a contrast agent due to concern about its effect on the fetus, emergency cesarean section was performed. Subsequently, a CT scan performed on the patient showed acute aortic dissection (Stanford B). Accordingly, antihypertensive therapy was commenced. In both cases, the patients were discharged after they recovered. Although case 2 did not meet criteria for Marfan syndrome, because of the hereditary disposition, we strongly suspect this was a Marfan syndrome pregnancy. This type of case is included in the case literature on cesarean and vigilant perinatal care is thought to be necessary.

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Isolated unilateral absence of the right pulmonary artery without any intracardiac anomaly is a rare congenital cardiovascular disorder. We performed a successful surgical reconstruction with autologous tissue of this anomaly. The patient was a 1-month-old boy who had been transferred to our center at 3 days of age because of tachypnea and heart murmur. Multi-detector CT and radial angiography imaging revealed isolated unilateral absence of the right pulmonary artery and left patent ductus arteriosus. Conservative treatment did not help his progressive heart failure and pulmonary hypertension due to an acute increase of pulmonary blood flow. Therefore surgical correction was determined to avoid the worsening of those symptoms. Under cardiopulmonary bypass, the right pulmonary artery branching off from the brachiocephalic artery was removed and anastomosed to the main pulmonary artery with an autologous pericardium roll. Symptoms improved postoperatively and he was discharged in good condition on the 21st of postoperative day. Cardiac catheterization, 3 months later, showed excellent results.

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A 71-year-old man who had been on peritoneal dialysis for 6 years was referred to our hospital for renal transplantation from a living donor. Preoperative echocardiography revealed diffuse severe hypokinesis, a left ventricular ejection fraction (LVEF) of 25%, and a pedicled floating mass in the right atrium. He had not exhibited positive symptoms of active endocarditis or metastatic malignant tumor, and the causes of cardiomyopathy seemed to be uremic and/or ischemic factors. Renal transplantation was postponed, and the extirpation of the mass in the right atrium was scheduled. LVEF improved to 48% 2 months following the induction of hemodialysis before the cardiac operation. Pathohistological findings of the extirpated intra-atrial mass showed sphachelus and fibrotic thrombus, which meant asymptomatic healed infective endocarditis. He recovered uneventfully, and underwent a living renal transplantation from living donor 5 months after the cardiac operation. LVEF further improved better to 56%, and his performance status was remarkably improved. These results imply that renal transplantation and hemodialysis in peritoneal dialysis patients with uremic cardiomyopathy can achive improvement of cardiac function and enable a safe cardiac operation.

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