Objectives: The risk of health impairment or disorder originating from intrauterine growth restriction has been discussed (hypothesis of Developmental Origins of Health and Disease: DOHaD hypothesis). However, the correlations between factors related to delivery and risks of health impairment or disorder
are unclear.
Methods: The authors investigated the rate of receiving public health and medical care (PHMC) in local health and medical service areas in Gunma Prefecture in groups divided by maternal age or birth order as well as its correlations with factors related to delivery (maternal age, birth order, birth weight, birth week, Caesarean section, delivery of twins or more) and health impairments or disorders (low birth weight, early delivery, respiratory disturbance, jaundice, hypoglycemia, small or large weight for delivery date [SFD], etc.) in babies (n = 232) who received PHMC during the years 2008-2012. The correlations were evaluated by multiple regression analysis.
Results: (1) Babies born to mothers of older maternal age (≥35 years) and third-born babies or higher had a high rate of receiving PHMC. (2) The relation factors for early delivery were older maternal age and Caesarean section, and those for low birth weight were early delivery, Caesarean section, delivery of twins or more, second-born or more babies, and others. (3) The relation factors for SFD or absolute value of SFD were low birth weight, delivery date, and others. (4) The relation factors for respiratory failure were early delivery, birth order, and others; that for jaundice was birth weight under 1,200 g; and those for hypoglycemia were low birth weight, SFD, and others. Some factors of the symptoms were interrelated. (5) There were reversed relations between birth weight under 2,000 g and birth weight under 1.200 g, among others. (6) The relation factors for older maternal age were early delivery and high birth order, and that for younger maternal age was first-born babies. (7) The relation factor for birth order was maternal age. (8) The relation factors for Caesarean section were older maternal age and second-born or more babies, and those for delivery of twins or more were Caesarean section.
Conclusions: Early delivery and low birth weight were related to the risks of health impairment or disorder included in SFD, respiratory failure, and others. Older maternal age and third-born babies or higher were related to early delivery and low birth weight. Therefore, babies born to mothers of older maternal age (≥35 years) and third-born babies or higher must have risks of health impairment or disorder mediated by early delivery and low birth weight. Health management, especially nutritional support based on the DOHaD hypothesis, should be provided according to the above risks of health impairment or disorder.
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