Journal of Oral Science
Online ISSN : 1880-4926
Print ISSN : 1343-4934
ISSN-L : 1343-4934
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Showing 1-16 articles out of 16 articles from the selected issue
Review
  • Irini Fagogeni, Joanna Metlerska, Mariusz Lipski, Tomasz Falgowski, Gó ...
    Type: Review
    2019 Volume 61 Issue 3 Pages 379-385
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: August 03, 2019
    JOURNALS FREE ACCESS

    There is some evidence of tooth discoloration after regenerative endodontic procedures. The aim of this review is to determine which materials used in regenerative procedures induce tooth discoloration. The authors searched six digital databases in February 2018: PubMed, Google Scholar, the Cochrane Library, Scopus, Web of Science, and Lilacs. As a result, 353 studies were found. Eleven studies that met the established criteria were selected. Analysis of the selected studies showed that most materials used in regenerative endodontic procedures have the potential to stain tooth tissues. To decrease tooth discoloration, sealing dentin with a dentin-bonding agent before the placement of a disinfectant paste and barrier materials should be considered. Only a small number of in vitro studies have been performed; therefore, further studies on this topic are warranted.

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Original
  • Kohei Okuyama, Tomofumi Naruse, Hirokazu Yutori, Souichi Yanamoto, Mas ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 386-390
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: June 19, 2019
    JOURNALS FREE ACCESS

    Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis, other associated autoimmune disease, and/or obstetrical morbidity along with persistent production of antiphospholipid antibodies. Because of the nature of this systemic disease, most patients are medicated with antithrombotic agents and abundant glucocorticoids. This study reports a cohort of 16 patients with APS, who underwent oral surgery between 2010 and 2017 at the Nagasaki University Hospital. Because oral antithrombotic therapy was continued in the perioperative period, all wounds were strictly closed by suturing to prevent postoperative bleeding. Perioperative laboratory dates and medications were assessed. All patients achieved local postoperative hemostasis and did not exhibit systemic complications. Moreover, there were no postoperative systemic and/or local infections. Oral surgeons should suture oral wounds and ensure local hemostasis to prevent postoperative bleeding. Because patients with APS are likely to develop thrombosis despite continued administration of antithrombotic medications, strict perioperative examination of blood coagulation is needed. Furthermore, it is important to consider the damage and stress caused due to oral surgery. Moreover, when necessary, glucocorticoid therapy should be carefully administered, in accordance with the degree of invasion and judgment of the attending physician.

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  • Barbara Manczyk, Joanna Gołda, Agnieszka Biniak, Katarzyna Reszelewska ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 391-397
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: June 10, 2019
    JOURNALS FREE ACCESS

    The pathogenesis of oral lichen planus (OLP) remains to be fully elucidated; however, certain psychoneurological factors may influence the onset and exacerbation of OLP. The aim of the present study is to evaluate the intensity of negative emotions in patients with OLP. A cross-sectional, questionnaire-based study was performed. The sample consisted of 52 subjects, comprising 26 patients with OLP (OLP group) and 26 controls (CTRL group). The Depression Anxiety Stress Scale 21 (DASS-21) was used for psychometric evaluation. The patients were also asked about their attitude toward the disease, treatment, and interference of the disease on daily life. The mean level of depression was 12.54 ± 6.6 in the OLP group and 7.69 ± 5.22 in the CTRL group (P = 0.006). The mean level of anxiety was 11.15 ± 7.95 in the OLP group and 6.62 ± 4.86 in the CTRL group (P = 0.018). The mean stress levels were 8.69 ± 7.06 and 3.85 ± 3.18 in the OLP and CTRL groups, respectively (P = 0.003). Severe and very severe scores of depression and very severe scores of anxiety and stress were present in the OLP group, whereas these emotions were normal in the majority of controls. Depression, stress, and anxiety may be involved in the pathogenesis and course of OLP.

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  • Shouhei Ogisawa, Keiji Shinozuka, Junya Aoki, Keiichi Yanagawa, Akio H ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 398-405
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: July 20, 2019
    JOURNALS FREE ACCESS

    Maxillomandibular advancement surgery is useful for treatment of sleep apnea. However, preoperative analysis and evaluation to facilitate decision-making regarding the direction and distance of maxillomandibular movement has primarily consisted of morphological analysis; physiological function is not evaluated. To improve preoperative prediction, this study used fluid simulation to investigate the characteristics and effects of airway changes associated with maxillomandibular movement. A one-dimensional model with general applicability was thus developed. Actual measurements of flow in patients were used in this fluid simulation, thus achieving an analysis closer to clinical conditions. The simulation results were qualitatively consistent with the actual measurements, which confirmed the usefulness of the simulation. In addition, the results of the one-dimensional model were within the error ranges of the actual measurements. The present results establish a foundation for using accumulating preoperative measurement data for more-precise prediction of postoperative outcomes.

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  • Naoko Sato, Shigeto Koyama, Takehiko Mito, Kuniyuki Izumita, Risa Ishi ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 406-411
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: July 24, 2019
    JOURNALS FREE ACCESS

    Oral rehabilitation with prosthodontic treatment considerably influences the well-being and quality of life of patients after ablative oral tumor surgery. This study evaluated the effects of implant-supported prostheses (ISPs) on oral health-related quality of life (OHRQoL) and chewing ability in 10 patients who requested ISPs after mandibular oral tumor resection. OHRQoL was assessed using the Japanese version of the Oral Health Impact Profile (OHIP-49) before and one year after ISP placement. Chewing ability, including self-assessed masticatory ability and occlusal force, was examined at one year after ISP placement. The initial mean total OHIP-49 score of 65.3 ± 9.79 decreased to 46.0 ± 8.14 at one year after ISP placement. Mean OHIP-49 score decreased in all domains, whereas self-assessed masticatory ability increased within one year of ISP placement. There were no significant differences between prosthesis types with respect to the mean OHIP-49 score or self-assessed masticatory ability. In conclusion, ISP placement improves OHRQoL and the self-assessed masticatory ability. Moreover, the prosthesis type might not significantly affect OHRQoL.

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  • Vinoda Sharma, Ahmed Hanafi, Christopher B. Overgaard, May Shaibani, K ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 412-417
    Published: 2019
    Released: August 28, 2019
    JOURNALS FREE ACCESS

    Periodontitis is an oral inflammatory disease that may have an association with coronary artery disease (CAD). Oral inflammatory load (OIL) can be quantified by assesment of oral polymorphonucleocytes (oPMN) in an oral rinse assay. The aim of the present study was to prospectively correlate OIL with CAD on angiography assessed in terms of SYNTAX score in patients presenting with stable angina or acute coronary syndrome (ACS). Consecutive eligible patients at a cardiac center were prospectively recruited. Two sets of oral rinse samples were collected before and after angiography, and the relationship between oPMN and SYNTAX score was assessed. Of the 137 patients recruited, 32.8% (n = 45) were female and 34.3% (n = 47) had diabetes mellitus. The overall mean oPMN count was low (mean 1.3 × 105 cells/mL), and the mean SYNTAX score was 7.4 ± 8.5. Most of the patients presented with stable angina (89.8%, n =123). Patients with oPMN ≥1.45 × 105 (periodontitis threshold) were more likely to be elderly males presenting with stable angina. No significant correlation was established between oPMN and SYNTAX score. Although this prospective study did not demonstrate a correlation between OIL and the severity of CAD, most patients had low mean oPMN values. Larger studies are required before definite conclusions can be drawn.

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  • Koji Ogata, Toru Takeshita, Yukie Shibata, Rie Matsumi, Shinya Kageyam ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 418-424
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: August 09, 2019
    JOURNALS FREE ACCESS

    Coffee is a widely consumed beverage containing organic compounds with antibacterial activity. To investigate its possible effect on the growth of oral indigenous microbiota, saliva samples collected from nine young adults were inoculated into brain heart infusion (BHI) medium with or without addition of coffee compounds and cultured at 37°C in 5% CO2 for 12 h. The total bacterial density and composition after cultivation for 0, 6, and 12 h were determined by quantitative PCR analysis and 16S rRNA gene sequencing, respectively. The increase in total bacterial load was significantly inhibited by addition of the coffee compounds. The microbiota was mostly composed of Streptococcus species after culture in BHI medium regardless of the addition of coffee compounds. The proportion of Streptococcus salivarius was significantly reduced after addition of coffee relative to that in untreated medium alone, whereas the proportions of Streptococcus mitis and Streptococcus infantis were increased. These results suggest that exposure to coffee affects the composition of the oral Streptococcus population, in addition to inhibiting the overall growth of salivary bacteria. Considered in the light of data from earlier epidemiological studies, it is possible to conclude that coffee consumption contributes to better health.

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  • Jennifer A. Hasslen, Wayne W. Barkmeier, Raymond S. Shaddy, Jared R. L ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 425-430
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: July 24, 2019
    JOURNALS FREE ACCESS

    The purpose of this study was to determine the depth of cure (DOC) of three resin-based composites (RBCs) using varying irradiance exposures with a corded light-emitting diode curing unit. DOCs for Filtek Z250, TPH Spectra, and Tetric EvoCeram Bulk Fill were determined using the International Organization for Standardization (ISO) Standard 4049. The RBCs were light-polymerized using three different power modes and manufacturer-recommended curing times. Irradiance was determined using a spectrometer sensor and the total energy density was calculated for each power mode and concomitant polymerization time. The DOC data were analyzed with a two-way analysis of variance and Tukey’s post hoc test. Tetric EvoCeram Bulk Fill produced significantly greater DOCs than TPH and Z250 (P < 0.05) for all three power mode settings. Overall, the DOC of Tetric EvoCeram Bulk Fill was greater than those of TPH and Z250 at all power settings, but the individual RBCs did not show a significant DOC difference among the three power settings (P > 0.05).

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  • Ting Wei, Jiayi Li, Huiqiang Sun, Mengyang Jiang, Yun Yang, Xiayan Luo ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 431-440
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: July 20, 2019
    JOURNALS FREE ACCESS

    Although airborne-particle abrasion, large-grit, acid-etched (SLA) surface technology can promote implant osseointegration; its mechanism remains unclear. By preparing the SLA titanium (Ti) plate (SLA Ti) and Polished Ti plate (Polished Ti), this experiment investigates the expression and distribution of the Yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) in MC3T3-E1 cells. In addition, gene YAP and TAZ silencing on the SLA Ti was conducted to observe changes in the osteoblast differentiation markers, runt-related transcription factor-2 (Runx2) and bone sialoprotein (BSP). The results demonstrated that SLA Ti surface microtopography could induce YAP/TAZ’s transfer from the cytoplasm to the nuclei of MC3T3-E1 cells. The expression of YAP/TAZ increased in terms of mRNA and protein. After silencing the YAP/TAZ genes, Runx2 and BSP decreased, suggesting that YAP/TAZ plays an important regulatory role in this process. Meanwhile, the results also showed that SLA microtopography enhanced the expression of integrins α1, α2, and β1. After silencing the integrin α1, α2, and β1 genes, YAP and TAZ decreased in terms of mRNA and protein. Therefore, this experiment was the first to confirm that SLA surface microtopography facilitates osteoblast differentiation by regulating YAP/TAZ and confirms that the process can be related to integrins α1, α2, and β1.

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  • José F. Gómez Clavel, Diana T. Vences, Allison C. Valdiviezo, Eric Peñ ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 441-446
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: July 26, 2019
    JOURNALS FREE ACCESS

    The aim of this study was to determine the correlation between laser fluorescence (LF) values of apparently sound tooth enamel and caries history. LF measurements were recorded from six sound enamel tooth surfaces in each of 346 subjects aged 8-25 years. Caries experience was evaluated using the decayed, missing, and filled tooth (DMFT) index and the International Caries Detection and Assessment System (ICDAS). To measure differences between the unrestored and restored tooth groups, an unpaired two-sample t-test was used. To assess the relationship between LF of sound enamel and caries experience based on the DMFT and ICDAS, Pearson’s correlation coefficient and linear regression analyses were used. The LF values of sound dental enamel in subjects with no history of invasive dental treatment were highly correlated with caries experience, as measured by the DMFT index (R = 0.76) and ICDAS (R = 0.7). The LF values of sound enamel in subjects with a history of previous invasive dental treatment were weakly correlated with caries experience, as measured by the DMFT index (R = 0.33), and moderately correlated with the ICDAS values (R = 0.66). The LF value of clinically healthy tooth enamel correlates with caries status based on the DMFT or ICDAS.

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  • Cagatay Dayan, Burim Kiseri, Burc Gencel, Hanefi Kurt, Necat Tuncer
    Type: research-article
    2019 Volume 61 Issue 3 Pages 447-453
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: July 24, 2019
    JOURNALS FREE ACCESS

    The aim of the present study is to evaluate the wear resistance and microhardness of various interim fixed prosthesis materials with different chemical compositions and curing methods. One heat-cured and four self-cured acrylic resins, and three self-cured, one light-cured, and one dual-cured composite-based materials were tested. For microhardness, samples from each group were tested after storing either at 37°C in artificial saliva for 7 days, followed by thermocycling, or in distilled water solution at 37°C for 24 h. For the evaluation of wear, the remaining samples were evaluated using a 3D scanner and a surface analysis program before loading in the chewing simulator and after every 10,000 cycles. There was a significant difference in wear behavior among the materials tested at both 10,000 and 20,000 cycles (P < 0.001). Microhardness and wear resistance were significantly different between acrylic and composite materials.

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  • Rand Al-Obaidi, Hamideh Salehi, Alban Desoutter, Hervé Tassery, Frédér ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 454-458
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: July 24, 2019
    JOURNALS FREE ACCESS

    The present study compared two pH-cycling models designed to induce subsurface lesions (SLs) with a less demineralized surface layer on teeth, with the aim of developing new technologies for assessment of such lesions by examining the performance of confocal Raman microscopy for detection of white spot lesions (WSLs). Twelve sound premolars were exposed to two sets of model conditions (A, B) designed to induce SLs. Teeth on which white lesions had formed in vivo were used as positive controls. All specimens were inspected using an intraoral camera and Raman microscopy to detect small changes in the appearance and structure of the enamel. Changes in the natural color of the teeth during the treatment were recorded via the camera. Phosphate maps with their spectra were constructed from the phosphate peak at 960 cm−1. The depth of lesions was measured on the basis of variations in phosphate peak intensity. Protocol B was reliable for reproducing SLs in a relatively short period. Both protocols had intrinsic limitations in not completely simulating the complex intraoral conditions leading to WSL formation with respect to lesion depth and preservation of an intact surface layer. Raman microscopy can be considered the gold standard for analysis of hard tissue mineralization.

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  • Rana Asano, Shiho Otake, Kosuke Nozaki, Keiichi Yoshida, Hiroyuki Miur ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 459-467
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: August 03, 2019
    JOURNALS FREE ACCESS

    This experiment assessed the effect of elapsed time between air abrasion and bonding on tensile bond strength (TBS) between computer-aided design/computer-aided manufacturing (CAD/CAM) composite resin blocks and luting agents. Specimens were divided into eight groups classified by block type (Estelite Block or HC Block), elapsed time after air abrasion (none [D0] or 1 week [D7]), luting agent type (Estecem [ESC] or Rely X Ultimate [RLU]), and polymerization condition (chemical cured [CC] or light cured [LC]). In the CC+ESC group, TBS was significantly higher at D0 than at D7. There was also a significant difference between blocks in all groups except the LC+ESC group. Scanning electron microscopy and atomic force microscopy were used to observe the surfaces of blocks after air abrasion and indicated that blocks absorbed water in air with elapsed time, which affected TBS between CAD/CAM composite resin blocks and luting agents.

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  • Hye-Min Ju, Yong-Woo Ahn, Sung-Hee Jeong, Hye-Mi Jeon, Kyung-Hee Kim, ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 468-474
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: July 24, 2019
    JOURNALS FREE ACCESS

    This retrospective study aims to investigate the proportion and characteristics of patients who perceive dental treatment (DT) as a cause of oral mucosal lesions (OMLs). A total of 2,302 patients with OMLs visited the Oral Medicine Department of Pusan National University Dental Hospital. The patients were divided into a study group (280 patients who perceived DT as a cause of OMLs) and a control group (300 randomly selected patients). Percentages of DT types, clinical characteristics, and the frequencies of diagnoses and chief complaint (CC) sites were analyzed in both groups. Among the patients with OMLs, 12.2% attributed OMLs to DT. Among the diagnoses, allergic reaction (AR) and traumatic ulcer/irritation (TU) were significantly more frequent in the study group. The DT types most frequently perceived as the cause of OMLs were implants. According to patients, TU and candida occurred most frequently following denture placement (68-79%), whereas oral lichen planus and AR occurred most commonly following implant treatment (52-53%). The gingiva was significantly more frequent as the CC site in the study group than in the control group (P < 0.05 for all outcomes). It is important to inform patients of the potential complications of DT and the importance of regular check-ups.

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  • Hajime Sakurai, Megumi Yokoyama, Osamu Katsumata-Kato, Junko Fujita-Yo ...
    Type: research-article
    2019 Volume 61 Issue 3 Pages 475-480
    Published: 2019
    Released: August 28, 2019
    [Advance publication] Released: August 03, 2019
    JOURNALS FREE ACCESS

    Salivary gland atrophy and consequent hyposalivation are serious problems in clinical dentistry, as saliva regulates the environment of the oral cavity. To clarify the mechanisms underlying salivary gland dysfunction, a system for primary culture of parotid acinar cells has been established. It has been reported previously that the process of cell isolation from parotid glands triggers stress signaling mediated by Src and p38 mitogen-activated protein (MAP) kinase (p38), leading to dedifferentiation of acinar cells, and that an nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor suppresses this activation of Src and p38, suggesting that reactive oxygen species initiate the dedifferentiation signal. The present study examined the effect of a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (also termed MCI-186 or edaravone), on activation of the stress signal and the secretory function of parotid acinar cells. Activation of p38 during cell isolation was suppressed by addition of MCI-186. The retention of the activity of amylase, a major salivary protein, and the number of amylase-containing secretory granules were improved by isolation and culture in the presence of MCI-186. In addition, calcium elevation upon stimulation with a muscarinic agonist was higher in MCI-186-treated cells than in untreated cells. These results suggest that MCI-186 (edaravone) is a promising agent for prevention of salivary gland dysfunction.

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Short communication
  • Yoshinori Sasai, Yusuke Suzuki, Yoshimasa Takeuchi
    Type: Short communication
    Subject area: Short communication
    2019 Volume 61 Issue 3 Pages 481-482
    Published: 2019
    Released: August 28, 2019
    JOURNALS FREE ACCESS

    The social security system, including the national health insurance system, in Japan has been maintained at a world-class level since 1974. However, an increase in the number of elderly people, and a decrease in the working generation, caused by a declining birthrate, represents a serious issue for the system both in the present and future. This report analyzes the key problems in the current insurance system and also considers how they can be handled in the future.

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