Several skin problems are considered as complications of obesity, but there have been few studies on their relationships. Furthermore, the effect of weight loss on skin conditions remains unclear. This study investigated the associations of skin problems and function with severity of obesity and degree of weight loss. A non-randomized crossover study was conducted for participants with a body mass index(BMI)≥25. Participants underwent a weight loss program for three months. Skin conditions including stratum corneum moisture, skin surface pH, transepidermal water loss, skin deformation(R0)and elasticity(R2)were evaluated at the abdomen, arm and thigh. Twenty-two participants underwent the first phase of the program, and 19 continued during the second phase. The prevalence of intertrig-like(p=0.020)and acanthosis nigricans-like skin conditions(p=0.018)were significantly higher among the participants with BMI>27.5 than among those with BMI<27.5. At the end of the program, BMI was positively associated with skin pH,(p=0.013 to p=0.044)and negatively with R0(p=0.001 to p=0.044). In both groups, BMI was significantly decreased during the program(repeated ANOVA p<0.001). The percentage of BMI reduction was associated with the percentage of R0 increase at midpoint(p=0.001 to p=0.008), and skin pH decrease at the end of the program(p<0.001 to p=0.045). The severity of obesity was related to specific skin problems and skin functional change, especially increased pH and decreased skin deformation. It is suggested that these skin functional changes can be reversed by weight reduction.
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